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    mei-2 Meiotic spindle formation protein 2 [ Caenorhabditis elegans ]

    Gene ID: 172374, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mei-2
    Official Full Name
    Meiotic spindle formation protein 2
    Primary source
    WormBase:WBGene00003184
    Locus tag
    CELE_F57B10.12
    See related
    AllianceGenome:WB:WBGene00003184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Contributes to microtubule severing ATPase activity. Involved in embryo development; meiotic spindle organization; and microtubule depolymerization. Located in cytoplasm; nucleus; and spindle pole. Part of katanin complex. Is expressed in germ line. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mei-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (6564749..6565852, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GOLD domain-containing protein Neighboring gene BAG family molecular chaperone regulator 1 Neighboring gene Protein MRVI1;Thyroid receptor-interacting protein 11 Neighboring gene 2,3-bisphosphoglycerate-independent phosphoglycerate mutase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Combinatorial and antagonistic effects of tubulin glutamylation and glycylation on katanin microtubule severing. Szczesna E, et al. Dev Cell, 2022 Nov 7. PMID 36347241, Free PMC Article
    2. Cellular Samurai: katanin and the severing of microtubules. Quarmby L. J Cell Sci, 2000 Aug. PMID 10910766
    3. Severing enzymes amplify microtubule arrays through lattice GTP-tubulin incorporation. Vemu A, et al. Science, 2018 Aug 24. PMID 30139843, Free PMC Article
    4. Structural basis for disassembly of katanin heterododecamers. Nithianantham S, et al. J Biol Chem, 2018 Jul 6. PMID 29752405, Free PMC Article
    5. Microtubule-severing activity of the AAA+ ATPase Katanin is essential for female meiotic spindle assembly. Joly N, et al. Development, 2016 Oct 1. PMID 27578779

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans.
      Title: Microtubule-binding domains in Katanin p80 subunit are essential for severing activity in C. elegans.
    2. Purified MEI-1/MEI-2 complexes preferentially sever at intersections between two microtubules and directly bundle microtubules in vitro.
      Title: Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to microtubule severing ATPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of katanin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Meiotic spindle formation protein 2
    NP_491894.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6564749..6565852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059493.8 → NP_491894.1  Meiotic spindle formation protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491894.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44740
      Conserved Domains (1) summary
      pfam13925
      Location:161 → 253
      Katanin_con80; con80 domain of Katanin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44740.1

    Gene LinkOut

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