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    rol-3 Protein roller-3 [ Caenorhabditis elegans ]

    Gene ID: 179204, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rol-3
    Official Full Name
    Protein roller-3
    Primary source
    WormBase:WBGene00004395
    Locus tag
    CELE_C16D9.2
    See related
    AllianceGenome:WB:WBGene00004395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity and protein kinase activity. Involved in embryo development and locomotion. Located in cell leading edge and cell periphery. Is expressed in several structures, including body wall musculature; head; hypodermis; vulval muscle; and vulval precursor cell. Orthologous to human ROS1 (ROS proto-oncogene 1, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rol-3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    28
    Sequence:
    Chromosome: V; NC_003283.11 (8228276..8238409, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aurora kinase Neighboring gene ncRNA Neighboring gene BBSome-interacting protein 1 Neighboring gene Paired box protein 1 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Met Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Uncharacterized protein Neighboring gene Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ortholog of the human proto-oncogene ROS1 is required for epithelial development in C. elegans. Jones MR, et al. Genesis, 2013 Aug. PMID 23733356, Free PMC Article
    2. Mutagenesis in Caenorhabditis elegans. II. A spectrum of mutational events induced with 1500 r of gamma-radiation. Rosenbluth RE, et al. Genetics, 1985 Mar. PMID 3979812, Free PMC Article
    3. Genetic studies of unusual loci that affect body shape of the nematode Caenorhabditis elegans and may code for cuticle structural proteins. Kusch M, et al. Genetics, 1986 Jul. PMID 3732788, Free PMC Article
    4. Genetic organization of the unc-60 region in Caenorhabditis elegans. McKim KS, et al. Genetics, 1988 Jan. PMID 8608931, Free PMC Article
    5. Caenorhabditis elegans Aurora A kinase AIR-1 is required for postembryonic cell divisions and germline development. Furuta T, et al. Genesis, 2002 Dec. PMID 12434334

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ROL-3 is essential for epithelial development
      Title: The ortholog of the human proto-oncogene ROS1 is required for epithelial development in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein roller-3
    NP_001256097.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8228276..8238409 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269168.3 → NP_001256097.1  Protein roller-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D7SFL6, Q8I7I3, Q8I7I4, Q8I7I5
      Conserved Domains (4) summary
      smart00221
      Location:1966 → 2232
      STYKc; Protein kinase; unclassified specificity
      cd00063
      Location:1542 → 1636
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00192
      Location:1970 → 2233
      PTKc; Catalytic domain of Protein Tyrosine Kinases
      pfam00041
      Location:1664 → 1749
      fn3; Fibronectin type III domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I7I5.2

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