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    fbxw11a F-box and WD repeat domain containing 11a [ Danio rerio (zebrafish) ]

    Gene ID: 334373, updated on 4-Jan-2025

    Summary

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    Official Symbol
    fbxw11aprovided by ZNC
    Official Full Name
    F-box and WD repeat domain containing 11aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6305
    See related
    Ensembl:ENSDARG00000104806 AllianceGenome:ZFIN:ZDB-GENE-030131-6305
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    btrc2; fbxw11; fbxw1b; fbxw11b; wu:fd14d12; wu:fi43f07
    Summary
    Predicted to enable snoRNA binding activity. Acts upstream of or within sprouting angiogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of small-subunit processome. Is expressed in brain; head mesenchyme; and retina. Orthologous to human FBXW11 (F-box and WD repeat domain containing 11). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See fbxw11a in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (2549807..2588191, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003335280.1 (28054..67931)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene microRNA 733 Neighboring gene uncharacterized LOC137487557 Neighboring gene fibroblast growth factor 18a Neighboring gene eukaryotic translation termination factor 1a Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 Neighboring gene uncharacterized LOC137487558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies. Holt RJ, et al. Am J Hum Genet, 2019 Sep 5. PMID 31402090, Free PMC Article
    2. Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development. Draper BW, et al. Development, 2003 Oct. PMID 12925590
    3. SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. Shaik S, et al. J Exp Med, 2012 Jul 2. PMID 22711876, Free PMC Article
    4. Splice blocking of zygotic sox31 leads to developmental arrest shortly after Mid-Blastula Transition and induces apoptosis in zebrafish. Hu SN, et al. FEBS Lett, 2012 Feb 3. PMID 22209980
    5. Differential response of multiple zebrafish hepatic F-box protein genes to 17alpha-ethinylestradiol treatment. Zheng H, et al. J Environ Sci (China), 2011. PMID 21793410

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sprouting angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    F-box and WD repeat domain-containing 11-A
    Names
    F-box and WD-40 domain protein 11
    F-box and WD-40 domain protein 11a
    F-box/WD repeat-containing protein 11a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201310.1 → NP_958467.1  F-box and WD repeat domain-containing 11-A

      See identical proteins and their annotated locations for NP_958467.1

      Status: PROVISIONAL

      Source sequence(s)
      BC045356
      UniProtKB/Swiss-Prot
      A0A2R8RWN9, Q6PGW4
      Related
      ENSDARP00000139358.1, ENSDART00000167293.3
      Conserved Domains (5) summary
      COG2319
      Location:212 → 506
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:225 → 503
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam12125
      Location:63 → 101
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:105 → 152
      F-box-like; F-box-like
      sd00039
      Location:228 → 263
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      2549807..2588191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173069.5 → XP_005173126.1  F-box and WD repeat domain-containing 11-A isoform X1

      UniProtKB/Swiss-Prot
      A0A2R8QFQ6, A0A2R8RWN9, Q6PGW4, Q7ZVZ1
      Related
      ENSDARP00000151798.1, ENSDART00000188082.1
      Conserved Domains (4) summary
      cd00200
      Location:260 → 538
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:263 → 298
      7WD40; WD40 repeat [structural motif]
      pfam12125
      Location:98 → 136
      Beta-TrCP_D; D domain of beta-TrCP
      pfam12937
      Location:140 → 187
      F-box-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A2R8QFQ6.1 GenPept UniProtKB/Swiss-Prot:A0A2R8QFQ6

    Gene LinkOut

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