dhodh dihydroorotate dehydrogenase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dhodhprovided by ZNC
Official Full Name: dihydroorotate dehydrogenaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3157
See related: Ensembl:ENSDARG00000051889 AllianceGenome:ZFIN:ZDB-GENE-030131-3157
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fc29a01; zgc:103492
Summary: Predicted to enable dihydroorotate dehydrogenase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleotide biosynthetic process. Predicted to be located in membrane and mitochondrion. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (56517402..56529527)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (56215991..56228116)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DHODH inhibition led to a marked decrease in melanoma growth both in vitro and in xenograft studies
Title: DHODH modulates transcriptional elongation in the neural crest and melanoma.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dihydroorotate dehydrogenase (quinone) activity	IEA Inferred from Electronic Annotation more info
enables dihydroorotate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydroorotate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine ribonucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dihydroorotate dehydrogenase (quinone), mitochondrial

NP_001008608.1

EC 1.3.98.1

XP_005166619.1

EC 1.3.98.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008608.1 → NP_001008608.1 dihydroorotate dehydrogenase (quinone), mitochondrial

See identical proteins and their annotated locations for NP_001008608.1

Status: PROVISIONAL

Source sequence(s)

BC086819

UniProtKB/TrEMBL

Q5PR57

Related

ENSDARP00000068087.3, ENSDART00000073597.4

Conserved Domains (2) summary

PLN02826
Location:15 → 393

PLN02826; dihydroorotate dehydrogenase

cd04738
Location:44 → 372

DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

56517402..56529527

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166562.4 → XP_005166619.1 dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8M2BE38

Conserved Domains (2) summary

PLN02826
Location:15 → 392

PLN02826; dihydroorotate dehydrogenase

cd04738
Location:44 → 371

DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...