moc-5 GTP 3',8-cyclase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: moc-5
Official Full Name: GTP 3',8-cyclase
Primary source: WormBase:WBGene00009885
Locus tag: CELE_F49E2.1
See related: AllianceGenome:WB:WBGene00009885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be part of molybdopterin synthase complex. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See moc-5 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (9561841..9565981, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

F49E2.1 (e-PCR)
- UniSTS:314399

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables GTP 3',8'-cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTP 3',8'-cyclase activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables cyclic pyranopterin monophosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclic pyranopterin monophosphate synthase activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in Mo-molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in Mo-molybdopterin cofactor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of molybdopterin synthase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GTP 3',8-cyclase

NP_001343868.1

Confirmed by transcript evidence

NP_001380230.1

Confirmed by transcript evidence

NP_509611.3

Confirmed by transcript evidence

NP_509612.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

9561841..9565981 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077211.7 → NP_509612.2 GTP 3',8-cyclase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509612.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A2C9C399, A0A2C9C3F0, Q20624, Q8T8M9, Q8T8N0

Conserved Domains (4) summary

cd01335
Location:78 → 258

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

cd01420
Location:454 → 589

MoaC_PE; MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine ...

TIGR02666
Location:67 → 391

moaA; molybdenum cofactor biosynthesis protein A, bacterial

pfam06463
Location:244 → 371

Mob_synth_C; Molybdenum Cofactor Synthesis C
NM_077210.8 → NP_509611.3 GTP 3',8-cyclase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509611.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20624

Conserved Domains (3) summary

cd01335
Location:78 → 258

Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...

TIGR02666
Location:67 → 389

moaA; molybdenum cofactor biosynthesis protein A, bacterial

pfam06463
Location:244 → 371

Mob_synth_C; Molybdenum Cofactor Synthesis C
NM_001392824.1 → NP_001380230.1 GTP 3',8-cyclase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cl00242
Location:1 → 39

MoaC; MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor ...
NM_001356794.4 → NP_001343868.1 GTP 3',8-cyclase [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (2) summary

PLN02951
Location:63 → 386

PLN02951; Molybderin biosynthesis protein CNX2

cl00242
Location:442 → 475

MoaC; MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor ...