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    fbn-1 EGF-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176076, updated on 2-Nov-2024

    Summary

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    Official Symbol
    fbn-1
    Official Full Name
    EGF-like domain-containing protein
    Primary source
    WormBase:WBGene00022816
    Locus tag
    CELE_ZK783.1
    See related
    AllianceGenome:WB:WBGene00022816
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be located in membrane. Is expressed in vulval cell. Used to study connective tissue disease. Human ortholog(s) of this gene implicated in several diseases, including CREST syndrome; Weill-Marchesani syndrome; aortic disease (multiple); autosomal dominant isolated ectopia lentis 1; and bone disease (multiple). Orthologous to human FBN1 (fibrillin 1); FBN2 (fibrillin 2); and FBN3 (fibrillin 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See fbn-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    25
    Sequence:
    Chromosome: III; NC_003281.10 (7625386..7641078)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Leptin receptor gene-related protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene Uridine and thymidine phosphorylase Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Epithelial Shaping by Diverse Apical Extracellular Matrices Requires the Nidogen Domain Protein DEX-1 in Caenorhabditis elegans. Cohen JD, et al. Genetics, 2019 Jan. PMID 30409789, Free PMC Article
    2. Fluorescence techniques in developmental biology. Veerapathiran S, et al. J Biosci, 2018 Jul. PMID 30002271
    3. FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis. Kelley M, et al. Elife, 2015 Mar 23. PMID 25798732, Free PMC Article
    4. Functional genomic analysis of C. elegans molting. Frand AR, et al. PLoS Biol, 2005 Oct. PMID 16122351, Free PMC Article
    5. Effectors of anterior morphogenesis in C. elegans embryos. Balasubramaniam B, et al. Biol Open, 2023 Jul 15. PMID 37345480, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. fbn-1 was required specifically within the epidermis and FBN-1 was expressed in epidermal cells and secreted to the apical surface as a putative component of the embryonic sheath.
      Title: FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    EGF-like domain-containing protein
    NP_001263709.1
    • Confirmed by transcript evidence
    NP_001263711.1
    • Confirmed by transcript evidence
    NP_001263712.1
    • Confirmed by transcript evidence
    NP_001263714.1
    • Confirmed by transcript evidence
    NP_001263715.1
    • Confirmed by transcript evidence
    NP_001263716.1
    • Confirmed by transcript evidence
    NP_001263717.1
    • Confirmed by transcript evidence
    NP_001263718.1
    • Confirmed by transcript evidence
    NP_498670.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7625386..7641078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066269.6 → NP_498670.2  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498670.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G4SPX0, Q23587
      Conserved Domains (8) summary
      smart00179
      Location:1699 → 1740
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:2344 → 2580
      ZP; Zona pellucida (ZP) domain
      cd00054
      Location:1606 → 1640
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00100
      Location:2484 → 2577
      Zona_pellucida; Zona pellucida-like domain
      pfam05109
      Location:916 → 1381
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07645
      Location:220 → 255
      EGF_CA; Calcium-binding EGF domain
      pfam10310
      Location:1274 → 1369
      DUF2413; Protein of unknown function (DUF2413)
      pfam12947
      Location:2296 → 2331
      EGF_3; EGF domain

    2. NM_001276782.4 → NP_001263711.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263711.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7J4C8
      Conserved Domains (8) summary
      smart00179
      Location:1699 → 1740
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:2436 → 2672
      ZP; Zona pellucida (ZP) domain
      cd00054
      Location:1606 → 1640
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00100
      Location:2576 → 2669
      Zona_pellucida; Zona pellucida-like domain
      pfam05109
      Location:916 → 1381
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07645
      Location:220 → 255
      EGF_CA; Calcium-binding EGF domain
      pfam10310
      Location:1274 → 1369
      DUF2413; Protein of unknown function (DUF2413)
      pfam12947
      Location:2388 → 2423
      EGF_3; EGF domain

    3. NM_001276783.3 → NP_001263712.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7LHV8
      Conserved Domains (8) summary
      smart00179
      Location:1699 → 1740
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:2413 → 2649
      ZP; Zona pellucida (ZP) domain
      cd00054
      Location:1606 → 1640
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00100
      Location:2553 → 2646
      Zona_pellucida; Zona pellucida-like domain
      pfam05109
      Location:916 → 1381
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07645
      Location:220 → 255
      EGF_CA; Calcium-binding EGF domain
      pfam10310
      Location:1274 → 1369
      DUF2413; Protein of unknown function (DUF2413)
      pfam12947
      Location:2365 → 2400
      EGF_3; EGF domain

    4. NM_001276787.4 → NP_001263716.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7J4C9
      Conserved Domains (8) summary
      smart00179
      Location:1699 → 1740
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:2313 → 2549
      ZP; Zona pellucida (ZP) domain
      cd00054
      Location:1606 → 1640
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00100
      Location:2453 → 2546
      Zona_pellucida; Zona pellucida-like domain
      pfam05109
      Location:916 → 1381
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07645
      Location:220 → 255
      EGF_CA; Calcium-binding EGF domain
      pfam10310
      Location:1274 → 1369
      DUF2413; Protein of unknown function (DUF2413)
      pfam12947
      Location:2265 → 2300
      EGF_3; EGF domain

    5. NM_001276780.3 → NP_001263709.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263709.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I6Z0I7
      Conserved Domains (8) summary
      smart00179
      Location:1701 → 1742
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:2438 → 2674
      ZP; Zona pellucida (ZP) domain
      cd00054
      Location:1608 → 1642
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00100
      Location:2578 → 2671
      Zona_pellucida; Zona pellucida-like domain
      pfam05109
      Location:918 → 1383
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07645
      Location:220 → 255
      EGF_CA; Calcium-binding EGF domain
      pfam10310
      Location:1276 → 1371
      DUF2413; Protein of unknown function (DUF2413)
      pfam12947
      Location:2390 → 2425
      EGF_3; EGF domain

    6. NM_001276785.3 → NP_001263714.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7K4J2
      Conserved Domains (8) summary
      smart00179
      Location:1699 → 1740
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:2391 → 2627
      ZP; Zona pellucida (ZP) domain
      cd00054
      Location:1606 → 1640
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00100
      Location:2531 → 2624
      Zona_pellucida; Zona pellucida-like domain
      pfam05109
      Location:916 → 1381
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07645
      Location:220 → 255
      EGF_CA; Calcium-binding EGF domain
      pfam10310
      Location:1274 → 1369
      DUF2413; Protein of unknown function (DUF2413)
      pfam12947
      Location:2343 → 2378
      EGF_3; EGF domain

    7. NM_001276786.3 → NP_001263715.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263715.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7LFE6
      Conserved Domains (8) summary
      smart00179
      Location:1699 → 1740
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:2360 → 2596
      ZP; Zona pellucida (ZP) domain
      cd00054
      Location:1606 → 1640
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00100
      Location:2500 → 2593
      Zona_pellucida; Zona pellucida-like domain
      pfam05109
      Location:916 → 1381
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07645
      Location:220 → 255
      EGF_CA; Calcium-binding EGF domain
      pfam10310
      Location:1274 → 1369
      DUF2413; Protein of unknown function (DUF2413)
      pfam12947
      Location:2312 → 2347
      EGF_3; EGF domain

    8. NM_001276788.3 → NP_001263717.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263717.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7LHV9
      Conserved Domains (8) summary
      smart00179
      Location:1699 → 1740
      EGF_CA; Calcium-binding EGF-like domain
      smart00241
      Location:2338 → 2574
      ZP; Zona pellucida (ZP) domain
      cd00054
      Location:1606 → 1640
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00100
      Location:2478 → 2571
      Zona_pellucida; Zona pellucida-like domain
      pfam05109
      Location:916 → 1381
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07645
      Location:220 → 255
      EGF_CA; Calcium-binding EGF domain
      pfam10310
      Location:1274 → 1369
      DUF2413; Protein of unknown function (DUF2413)
      pfam12947
      Location:2290 → 2325
      EGF_3; EGF domain

    9. NM_001276789.4 → NP_001263718.1  EGF-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263718.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I7K4J6
      Conserved Domains (6) summary
      PHA03255
      Location:2032 → 2171
      PHA03255; BDLF3; Provisional
      smart00179
      Location:1699 → 1740
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:1606 → 1640
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:220 → 255
      EGF_CA; Calcium-binding EGF domain
      pfam10310
      Location:1274 → 1369
      DUF2413; Protein of unknown function (DUF2413)
      pfam12947
      Location:140 → 170
      EGF_3; EGF domain
    Nucleotide Protein
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