U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Milr1 mast cell immunoglobulin-like receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59105, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Milr1provided by RGD
    Official Full Name
    mast cell immunoglobulin-like receptor 1provided by RGD
    Primary source
    RGD:620488
    See related
    EnsemblRapid:ENSRNOG00000042524 AllianceGenome:RGD:620488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mca32
    Summary
    Predicted to be involved in mast cell degranulation and negative regulation of mast cell activation. Predicted to be located in plasma membrane. Orthologous to human MILR1 (mast cell immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 38.5), Spleen (RPKM 28.8) and 3 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Milr1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (92184002..92205001)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (91684288..91705284)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94944243..94961795)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 83 Neighboring gene testis expressed 2 Neighboring gene platelet and endothelial cell adhesion molecule 1 Neighboring gene DNA polymerase gamma 2, accessory subunit Neighboring gene microRNA 3064 Neighboring gene DEAD-box helicase 5

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification and characterization of a novel surface antigen gene induced in mast cells activated through the high affinity IgE receptor. Pirozzi G, et al. J Immunol, 1995 Dec 15. PMID 7499870
    2. An immunoglobulin-like receptor, Allergin-1, inhibits immunoglobulin E-mediated immediate hypersensitivity reactions. Hitomi K, et al. Nat Immunol, 2010 Jul. PMID 20526344
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mast cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mast cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    allergin-1
    Names
    MCA-32
    allergy inhibitory receptor 1
    mast cell Ag-32
    mast cell antigen 32
    surface protein MCA-32

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410245.1 → NP_001397174.1  allergin-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    2. NM_021585.1 → NP_067596.1  allergin-1 isoform 1

      See identical proteins and their annotated locations for NP_067596.1

      Status: VALIDATED

      Source sequence(s)
      U39546
      UniProtKB/TrEMBL
      A0A0G2K456, A6HK54
      Related
      ENSRNOP00000072914.2, ENSRNOT00000078968.3
      Conserved Domains (2) summary
      smart00410
      Location:82 → 151
      IG_like; Immunoglobulin like
      pfam13895
      Location:74 → 158
      Ig_2; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      92184002..92205001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086732.2 → XP_038942660.1  allergin-1 isoform X8

      Conserved Domains (1) summary
      smart00409
      Location:3 → 72
      IG; Immunoglobulin

    2. XM_039086730.2 → XP_038942658.1  allergin-1 isoform X8

      Conserved Domains (1) summary
      smart00409
      Location:3 → 72
      IG; Immunoglobulin

    3. XM_039086729.2 → XP_038942657.1  allergin-1 isoform X8

      Conserved Domains (1) summary
      smart00409
      Location:3 → 72
      IG; Immunoglobulin

    4. XM_039086731.2 → XP_038942659.1  allergin-1 isoform X8

      Conserved Domains (1) summary
      smart00409
      Location:3 → 72
      IG; Immunoglobulin

    5. XM_017597497.3 → XP_017452986.1  allergin-1 isoform X3

      UniProtKB/TrEMBL
      A6HK55

    6. XM_039086726.2 → XP_038942654.1  allergin-1 isoform X4

      UniProtKB/TrEMBL
      A6HK55
      Conserved Domains (1) summary
      pfam13895
      Location:74 → 155
      Ig_2; Immunoglobulin domain

    7. XM_008768388.4 → XP_008766610.1  allergin-1 isoform X6

      UniProtKB/TrEMBL
      A6HK55
      Conserved Domains (2) summary
      smart00410
      Location:82 → 151
      IG_like; Immunoglobulin like
      pfam13895
      Location:74 → 158
      Ig_2; Immunoglobulin domain

    8. XM_039086725.2 → XP_038942653.1  allergin-1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K456, A6HK54
      Conserved Domains (1) summary
      pfam13895
      Location:74 → 155
      Ig_2; Immunoglobulin domain

    9. XM_008768389.4 → XP_008766611.1  allergin-1 isoform X7

      UniProtKB/TrEMBL
      A6HK55
      Conserved Domains (2) summary
      smart00410
      Location:82 → 151
      IG_like; Immunoglobulin like
      pfam13895
      Location:74 → 158
      Ig_2; Immunoglobulin domain

    10. XM_039086724.2 → XP_038942652.1  allergin-1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K456, A6HK54
      Conserved Domains (1) summary
      pfam13895
      Location:74 → 155
      Ig_2; Immunoglobulin domain

    11. XM_039086733.2 → XP_038942661.1  allergin-1 isoform X9

      UniProtKB/TrEMBL
      A0A0G2K456, A6HK54
      Conserved Domains (1) summary
      pfam13895
      Location:74 → 155
      Ig_2; Immunoglobulin domain

    12. XM_039086727.2 → XP_038942655.1  allergin-1 isoform X5

      UniProtKB/Swiss-Prot
      Q62875
      Conserved Domains (1) summary
      smart00409
      Location:30 → 99
      IG; Immunoglobulin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62875.2 GenPept UniProtKB/Swiss-Prot:Q62875

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools