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    frpr-18 FMRFamide peptide receptor frpr-18 [ Caenorhabditis elegans ]

    Gene ID: 179076, updated on 14-Nov-2024

    Summary

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    Official Symbol
    frpr-18
    Official Full Name
    FMRFamide peptide receptor frpr-18
    Primary source
    WormBase:WBGene00020586
    Locus tag
    CELE_T19F4.1
    See related
    AllianceGenome:WB:WBGene00020586
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables G protein-coupled receptor activity. Involved in G protein-coupled receptor signaling pathway; positive regulation of protein secretion; and sleep. Located in plasma membrane. Is expressed in enteric muscle and neurons. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See frpr-18 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (6870304..6873812)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Guanine nucleotide-binding protein alpha-10 subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional expression and characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in mammalian cells and yeast. Larsen MJ, et al. Int J Parasitol Drugs Drug Resist, 2013 Dec. PMID 24533288, Free PMC Article
    2. Molecular characterization of two G protein-coupled receptor splice variants as FLP2 receptors in Caenorhabditis elegans. Mertens I, et al. Biochem Biophys Res Commun, 2005 May 13. PMID 15809090
    3. frpr-18, a neuropeptide receptor, regulates organismal lifespan and stress tolerance in C. elegans. Ouaakki H, et al. MicroPubl Biol, 2023. PMID 37383174, Free PMC Article
    4. The Neuropeptides FLP-2 and PDF-1 Act in Concert To Arouse Caenorhabditis elegans Locomotion. Chen D, et al. Genetics, 2016 Nov. PMID 27585848, Free PMC Article
    5. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FMRFamide peptide receptor frpr-18
    NP_001343646.1
    • Confirmed by transcript evidence
    NP_001343861.1
    • Confirmed by transcript evidence
    NP_504746.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6870304..6873812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072345.7 → NP_504746.1  FMRFamide peptide receptor frpr-18 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504746.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A2C9C3N0, G5EEB1, G5EGC5, Q29XY6
      Conserved Domains (1) summary
      cd14978
      Location:6 → 299
      7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001356671.3 → NP_001343646.1  FMRFamide peptide receptor frpr-18 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14978
      Location:6 → 299
      7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001356672.4 → NP_001343861.1  FMRFamide peptide receptor frpr-18 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd14978
      Location:6 → 257
      7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

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