U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    miz-1 SP-RING-type domain-containing protein;Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565074, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    miz-1
    Official Full Name
    SP-RING-type domain-containing protein;Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein
    Primary source
    WormBase:WBGene00011259
    Locus tag
    CELE_R13.4
    See related
    AllianceGenome:WB:WBGene00011259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SUMO ligase activity and nuclear receptor coactivator activity. Predicted to be involved in protein sumoylation and regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Is expressed in several structures, including anal depressor muscle; nervous system; pharyngeal-intestinal valve; pharynx; and reproductive system. Orthologous to human ZMIZ2 (zinc finger MIZ-type containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See miz-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (10812399..10825979)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene Paired domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SP-RING-type domain-containing protein;Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein
    NP_001255512.1
    • Confirmed by transcript evidence
    NP_001255513.1
    • Confirmed by transcript evidence
    NP_001293986.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10812399..10825979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268583.3 → NP_001255512.1  Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255512.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21970
      Conserved Domains (4) summary
      pfam09606
      Location:122 → 330
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd00162
      Location:492 → 532
      RING_Ubox; SP-RING finger [structural motif]
      pfam18028
      Location:10 → 102
      Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
      cl17238
      Location:489 → 533
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. NM_001307057.4 → NP_001293986.1  Zmiz1 N-terminal tetratricopeptide repeat domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293986.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061AE46
      Conserved Domains (4) summary
      pfam09606
      Location:122 → 330
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cd00162
      Location:492 → 532
      RING_Ubox; SP-RING finger [structural motif]
      pfam18028
      Location:10 → 102
      Zmiz1_N; Zmiz1 N-terminal tetratricopeptide repeat domain
      cl17238
      Location:489 → 534
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. NM_001268584.3 → NP_001255513.1  SP-RING-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255513.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G1K845
      Conserved Domains (3) summary
      TIGR01628
      Location:31 → 155
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd00162
      Location:323 → 363
      RING_Ubox; SP-RING finger [structural motif]
      cl17238
      Location:320 → 364
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools