Brd4 bromodomain containing 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Brd4provided by RGD
Official Full Name: bromodomain containing 4provided by RGD
Primary source: RGD:1307282
See related: EnsemblRapid:ENSRNOG00000006770 AllianceGenome:RGD:1307282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including P-TEFb complex binding activity; lysine-acetylated histone binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation by host of viral transcription; positive regulation of T-helper 17 cell lineage commitment; and regulation of intracellular signal transduction. Predicted to act upstream of or within several processes, including inner cell mass cell proliferation; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of transcription elongation by RNA polymerase II. Predicted to be located in chromatin; condensed nuclear chromosome; and nucleoplasm. Predicted to be part of cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 6; colon cancer; and idiopathic pulmonary fibrosis. Orthologous to human BRD4 (bromodomain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 67.3), Thymus (RPKM 60.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (11866997..11946575, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (11216446..11296029, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (14222101..14303055, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation.
Title: Inhibition of CK2 Diminishes Fibrotic Scar Formation and Improves Outcomes After Ischemic Stroke via Reducing BRD4 Phosphorylation.
Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Title: Inhibition of spinal BRD4 alleviates pyroptosis and M1 microglia polarization via STING-IRF3 pathway in morphine-tolerant rats.
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling.
Title: Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling.
Bromodomain-containing protein 4 activates androgen receptor transcription and promotes ovarian fibrosis in PCOS.
Title: Bromodomain-containing protein 4 activates androgen receptor transcription and promotes ovarian fibrosis in PCOS.
Inhibition of BRD4 expression attenuates the inflammatory response and apoptosis by downregulating the HMGB-1/NF-kappaB signaling pathway following traumatic brain injury in rats.
Title: Inhibition of BRD4 expression attenuates the inflammatory response and apoptosis by downregulating the HMGB-1/NF-κB signaling pathway following traumatic brain injury in rats.
A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent transcription in rat striatal neurons.
Title: A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent transcription in rat striatal neurons.
LncRNA XIST silencing protects against sepsis-induced acute liver injury via inhibition of BRD4 expression.
Title: LncRNA XIST silencing protects against sepsis-induced acute liver injury via inhibition of BRD4 expression.
MiR-101-containing extracellular vesicles bind to BRD4 and enhance proliferation and migration of trophoblasts in preeclampsia.
Title: MiR-101-containing extracellular vesicles bind to BRD4 and enhance proliferation and migration of trophoblasts in preeclampsia.
Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
Title: Salvianic acid A alleviates chronic alcoholic liver disease by inhibiting HMGB1 translocation via down-regulating BRD4.
Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells.
Title: Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

RH130228 (e-PCR)
- UniSTS:213515

BE112151 (e-PCR)
- UniSTS:246066

RH129167 (e-PCR)
- UniSTS:212475

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables GTP-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables P-TEFb complex binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II C-terminal domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromosome segregation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner cell mass cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA damage checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein autophosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
part_of cyclin/CDK positive transcription elongation factor complex	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain-containing protein 4

NP_001094373.1

EC 3.1.1.31

XP_006241134.1

EC 3.1.1.31

XP_006241135.1

EC 3.1.1.31

XP_008763393.2

EC 3.1.1.31

XP_017450405.1

EC 3.1.1.31

XP_038935343.1

EC 3.1.1.31

XP_038935344.1

EC 3.1.1.31

XP_063119821.1

EC 3.1.1.31

XP_063119822.1

EC 3.1.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100903.1 → NP_001094373.1 bromodomain-containing protein 4

See identical proteins and their annotated locations for NP_001094373.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

D3ZGX8

Related

ENSRNOP00000070799.2, ENSRNOT00000091368.3

Conserved Domains (4) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1361 → 1403

BRD4_CDT; C-terminal domain of bromodomain protein 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

11866997..11946575 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263751.1 → XP_063119821.1 bromodomain-containing protein 4 isoform X4

UniProtKB/TrEMBL

D3ZGX8
XM_008765171.4 → XP_008763393.2 bromodomain-containing protein 4 isoform X2

UniProtKB/TrEMBL

D3ZGX8
XM_017594916.3 → XP_017450405.1 bromodomain-containing protein 4 isoform X3

UniProtKB/TrEMBL

A0A0G2JYV0, D3ZGX8

Related

ENSRNOP00000008963.8, ENSRNOT00000008963.9
XM_006241072.5 → XP_006241134.1 bromodomain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_006241134.1

UniProtKB/TrEMBL

D3ZGX8

Conserved Domains (4) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1361 → 1403

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_006241073.5 → XP_006241135.1 bromodomain-containing protein 4 isoform X1

See identical proteins and their annotated locations for XP_006241135.1

UniProtKB/TrEMBL

D3ZGX8

Conserved Domains (4) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1361 → 1403

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_063263752.1 → XP_063119822.1 bromodomain-containing protein 4 isoform X1

UniProtKB/TrEMBL

D3ZGX8
XM_039079415.2 → XP_038935343.1 bromodomain-containing protein 4 isoform X5

UniProtKB/TrEMBL

D3ZGX8

Conserved Domains (4) summary

cd05498
Location:206 → 307

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

PHA03247
Location:653 → 1101

PHA03247; large tegument protein UL36; Provisional

pfam17035
Location:462 → 526

BET; Bromodomain extra-terminal - transcription regulation

pfam17105
Location:1213 → 1255

BRD4_CDT; C-terminal domain of bromodomain protein 4
XM_039079416.2 → XP_038935344.1 bromodomain-containing protein 4 isoform X6

UniProtKB/TrEMBL

A0A8I5ZKZ4, A6K943

Related

ENSRNOP00000078464.1, ENSRNOT00000095545.2

Conserved Domains (3) summary

cd05497
Location:58 → 164

Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

cd05498
Location:354 → 455

Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...

pfam17035
Location:610 → 674

BET; Bromodomain extra-terminal - transcription regulation