Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Obscnprovided by RGD
Full Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEFprovided by RGD
Primary source: RGD:631335
See related: EnsemblRapid:ENSRNOG00000058068 AllianceGenome:RGD:631335
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305774
Summary: Predicted to enable several functions, including cytoskeletal protein binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and protein autophosphorylation. Located in M band and Z disc. Orthologous to human OBSCN (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 1663.2) and Heart (RPKM 448.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 122

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (44273686..44419275, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (43774113..43919718, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (45353185..45483570, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation.
Title: Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation.
obscurins are not restricted to striated muscles, but are abundantly expressed in several tissues and organs including brain, skin, kidney, liver, spleen, and lung.
Title: Obscurins: Goliaths and Davids take over non-muscle tissues.
Site-directed mutagenesis, blot overlays and surface plasmon resonance assays were used to study the contribution of the hydrophobic residues, V70, F71, I102 and I103 of small ankyrin-1 (sAnk1), to two different 30-mers of obscurin that bind sAnk1.
Title: Hydrophobic residues in small ankyrin 1 participate in binding to obscurin.
Results suggest that obscurin's rhoGEF domain signals at least in part by inducing rhoA expression and activation, and altering the expression of downstream kinases in vitro and in vivo.
Title: The rho-guanine nucleotide exchange factor domain of obscurin activates rhoA signaling in skeletal muscle.
A new ligand of obscurin at the M-band, MyBP-C slow variant-1 and suggest that their interaction contributes to the assembly of M-and A-bands, is identified.
Title: Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly.
Obscurin and ank1.5 localization in developing rat diaphragm
Title: Localization of ank1.5 in the sarcoplasmic reticulum precedes that of SERCA and RyR: relationship with the organization of obscurin in developing sarcomeres.
Titin mutations that have been linked to limb-girdle muscular dystrophy 2J (LGMD2J) or Salih myopathy weaken or abrogate titin-obscurin and titin-Obsl1 binding, and lead to obscurin mislocalization.
Title: Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies.
Early incorporation of Obscn into nascent sarcometres was studied, along with the implication for myofibril assembly during cardiac myogenesis.
Title: Early incorporation of obscurin into nascent sarcomeres: implication for myofibril assembly during cardiac myogenesis.
COOH-terminal region of obscurin interacts with sarcomeric myosin and may play a critical role in its ability to assemble into A bands in striated muscle.
Title: Obscurin regulates the organization of myosin into A bands.
high-resolution confocal microscopy to examine the dynamics of obscurin localization in cultures of rat cardiac myocytes during the assembly and disassembly of myofibrils
Title: Dynamics of obscurin localization during differentiation and remodeling of cardiac myocytes: obscurin as an integrator of myofibrillar structure.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Markers

RH140532 (e-PCR)
- UniSTS:222601

AA800048 (e-PCR)
- UniSTS:250573

RH134278 (e-PCR)
- UniSTS:217560

RH127871 (e-PCR)
- UniSTS:211181

GDB:182516 (e-PCR)
- UniSTS:155384

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	NAS Non-traceable Author Statement more info	PubMed
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-5-phosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info
enables titin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in M band	IDA Inferred from Direct Assay more info	PubMed
located_in M band	ISO Inferred from Sequence Orthology more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: obscurin

Names: obscurin-like

XP_038943147.1

EC 2.7.11.1

XP_038943148.1

EC 2.7.11.1

XP_038943169.1

EC 2.7.11.1

XP_038943171.1

EC 2.7.11.1

XP_038943173.1

EC 2.7.11.1

XP_038943174.1

EC 2.7.11.1

XP_038943176.1

EC 2.7.11.1

XP_038943177.1

EC 2.7.11.1

XP_038943178.1

EC 2.7.11.1

XP_063126174.1

EC 2.7.11.1

XP_063126175.1

EC 2.7.11.1

XP_063126176.1

EC 2.7.11.1

XP_063126177.1

EC 2.7.11.1

XP_063126178.1

EC 2.7.11.1

XP_063126179.1

EC 2.7.11.1

XP_063126180.1

EC 2.7.11.1

XP_063126181.1

EC 2.7.11.1

XP_063126182.1

EC 2.7.11.1

XP_063126183.1

EC 2.7.11.1

XP_063126184.1

EC 2.7.11.1

XP_063126185.1

EC 2.7.11.1

XP_063126186.1

EC 2.7.11.1

XP_063126187.1

EC 2.7.11.1

XP_063126188.1

EC 2.7.11.1

XP_063126189.1

EC 2.7.11.1

XP_063126190.1

EC 2.7.11.1

XP_063126191.1

EC 2.7.11.1

XP_063126192.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

44273686..44419275 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270116.1 → XP_063126186.1 obscurin isoform X15
XM_063270112.1 → XP_063126182.1 obscurin isoform X10
XM_063270115.1 → XP_063126185.1 obscurin isoform X14
XM_063270118.1 → XP_063126188.1 obscurin isoform X17
XM_063270109.1 → XP_063126179.1 obscurin isoform X7
XM_063270114.1 → XP_063126184.1 obscurin isoform X13
XM_063270110.1 → XP_063126180.1 obscurin isoform X8
XM_063270111.1 → XP_063126181.1 obscurin isoform X9
XM_039087250.1 → XP_038943178.1 obscurin isoform X24

Conserved Domains (11) summary

cd12025
Location:5983 → 6045

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:7917 → 7995

FN3; Fibronectin type 3 domain

cd00063
Location:4865 → 4950

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13239
Location:6263 → 6387

PH_Obscurin; Obscurin pleckstrin homology (PH) domain

pfam07679
Location:9 → 98

I-set; Immunoglobulin I-set domain

pfam13927
Location:6488 → 6567

Ig_3; Immunoglobulin domain

cd00096
Location:984 → 986

Ig; Ig strand A [structural motif]

cd20971
Location:6395 → 6485

IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains

cl02571
Location:6078 → 6254

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl11960
Location:984 → 1065

Ig; Immunoglobulin domain

cl21453
Location:6850 → 7106

PKc_like; Protein Kinases, catalytic domain
XM_039087246.1 → XP_038943174.1 obscurin isoform X21

Conserved Domains (11) summary

cd12025
Location:6247 → 6309

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:8181 → 8259

FN3; Fibronectin type 3 domain

cd00063
Location:5129 → 5214

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13239
Location:6527 → 6651

PH_Obscurin; Obscurin pleckstrin homology (PH) domain

pfam07679
Location:9 → 98

I-set; Immunoglobulin I-set domain

pfam13927
Location:6752 → 6831

Ig_3; Immunoglobulin domain

cd00096
Location:984 → 986

Ig; Ig strand A [structural motif]

cd20971
Location:6659 → 6749

IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains

cl02571
Location:6342 → 6518

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl11960
Location:984 → 1065

Ig; Immunoglobulin domain

cl21453
Location:7114 → 7370

PKc_like; Protein Kinases, catalytic domain
XM_039087249.1 → XP_038943177.1 obscurin isoform X23

Conserved Domains (11) summary

cd12025
Location:6071 → 6133

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:8005 → 8083

FN3; Fibronectin type 3 domain

cd00063
Location:4953 → 5038

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13239
Location:6351 → 6475

PH_Obscurin; Obscurin pleckstrin homology (PH) domain

pfam07679
Location:9 → 98

I-set; Immunoglobulin I-set domain

pfam13927
Location:6576 → 6655

Ig_3; Immunoglobulin domain

cd00096
Location:984 → 986

Ig; Ig strand A [structural motif]

cd20971
Location:6483 → 6573

IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains

cl02571
Location:6166 → 6342

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl11960
Location:984 → 1065

Ig; Immunoglobulin domain

cl21453
Location:6938 → 7194

PKc_like; Protein Kinases, catalytic domain
XM_039087245.1 → XP_038943173.1 obscurin isoform X20

Conserved Domains (11) summary

cd12025
Location:6335 → 6397

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:8269 → 8347

FN3; Fibronectin type 3 domain

cd00063
Location:5217 → 5302

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13239
Location:6615 → 6739

PH_Obscurin; Obscurin pleckstrin homology (PH) domain

pfam07679
Location:9 → 98

I-set; Immunoglobulin I-set domain

pfam13927
Location:6840 → 6919

Ig_3; Immunoglobulin domain

cd00096
Location:984 → 986

Ig; Ig strand A [structural motif]

cd20971
Location:6747 → 6837

IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains

cl02571
Location:6430 → 6606

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl11960
Location:984 → 1065

Ig; Immunoglobulin domain

cl21453
Location:7202 → 7458

PKc_like; Protein Kinases, catalytic domain
XM_039087248.1 → XP_038943176.1 obscurin isoform X22

Conserved Domains (11) summary

cd12025
Location:6159 → 6221

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:8093 → 8171

FN3; Fibronectin type 3 domain

cd00063
Location:5041 → 5126

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13239
Location:6439 → 6563

PH_Obscurin; Obscurin pleckstrin homology (PH) domain

pfam07679
Location:9 → 98

I-set; Immunoglobulin I-set domain

pfam13927
Location:6664 → 6743

Ig_3; Immunoglobulin domain

cd00096
Location:984 → 986

Ig; Ig strand A [structural motif]

cd20971
Location:6571 → 6661

IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains

cl02571
Location:6254 → 6430

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl11960
Location:984 → 1065

Ig; Immunoglobulin domain

cl21453
Location:7026 → 7282

PKc_like; Protein Kinases, catalytic domain
XM_039087243.1 → XP_038943171.1 obscurin isoform X19

Conserved Domains (11) summary

cd12025
Location:6423 → 6485

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:8357 → 8435

FN3; Fibronectin type 3 domain

cd00063
Location:5305 → 5390

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13239
Location:6703 → 6827

PH_Obscurin; Obscurin pleckstrin homology (PH) domain

pfam07679
Location:9 → 98

I-set; Immunoglobulin I-set domain

pfam13927
Location:6928 → 7007

Ig_3; Immunoglobulin domain

cd00096
Location:984 → 986

Ig; Ig strand A [structural motif]

cd20971
Location:6835 → 6925

IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains

cl02571
Location:6518 → 6694

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl11960
Location:984 → 1065

Ig; Immunoglobulin domain

cl21453
Location:7290 → 7546

PKc_like; Protein Kinases, catalytic domain
XM_063270106.1 → XP_063126176.1 obscurin isoform X4
XM_063270117.1 → XP_063126187.1 obscurin isoform X16
XM_063270108.1 → XP_063126178.1 obscurin isoform X6
XM_039087241.1 → XP_038943169.1 obscurin isoform X18

Conserved Domains (11) summary

cd12025
Location:6513 → 6575

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:8447 → 8525

FN3; Fibronectin type 3 domain

cd00063
Location:5395 → 5480

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13239
Location:6793 → 6917

PH_Obscurin; Obscurin pleckstrin homology (PH) domain

pfam07679
Location:9 → 98

I-set; Immunoglobulin I-set domain

pfam13927
Location:7018 → 7097

Ig_3; Immunoglobulin domain

cd00096
Location:984 → 986

Ig; Ig strand A [structural motif]

cd20971
Location:6925 → 7015

IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains

cl02571
Location:6608 → 6784

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl11960
Location:984 → 1065

Ig; Immunoglobulin domain

cl21453
Location:7380 → 7636

PKc_like; Protein Kinases, catalytic domain
XM_039087220.1 → XP_038943148.1 obscurin isoform X11

Conserved Domains (11) summary

cd12025
Location:6777 → 6839

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:8711 → 8789

FN3; Fibronectin type 3 domain

cd00063
Location:5659 → 5744

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13239
Location:7057 → 7181

PH_Obscurin; Obscurin pleckstrin homology (PH) domain

pfam07679
Location:9 → 98

I-set; Immunoglobulin I-set domain

pfam13927
Location:7282 → 7361

Ig_3; Immunoglobulin domain

cd00096
Location:984 → 986

Ig; Ig strand A [structural motif]

cd20971
Location:7189 → 7279

IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains

cl02571
Location:6872 → 7048

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl11960
Location:984 → 1065

Ig; Immunoglobulin domain

cl21453
Location:7644 → 7900

PKc_like; Protein Kinases, catalytic domain
XM_039087219.1 → XP_038943147.1 obscurin isoform X3

Conserved Domains (11) summary

cd12025
Location:6865 → 6927

SH3_Obscurin_like; Src homology 3 domain of Obscurin and similar proteins

smart00060
Location:8799 → 8877

FN3; Fibronectin type 3 domain

cd00063
Location:5747 → 5832

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd13239
Location:7145 → 7269

PH_Obscurin; Obscurin pleckstrin homology (PH) domain

pfam07679
Location:9 → 98

I-set; Immunoglobulin I-set domain

pfam13927
Location:7370 → 7449

Ig_3; Immunoglobulin domain

cd00096
Location:984 → 986

Ig; Ig strand A [structural motif]

cd20971
Location:7277 → 7367

IgI_1_Titin-A168_like; First immunoglobulin-like domains A168 within the A-band segment of human cardiac titin, and similar domains; a member of the I-set of IgSF domains

cl02571
Location:6960 → 7136

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cl11960
Location:984 → 1065

Ig; Immunoglobulin domain

cl21453
Location:7732 → 7988

PKc_like; Protein Kinases, catalytic domain
XM_063270105.1 → XP_063126175.1 obscurin isoform X2
XM_063270107.1 → XP_063126177.1 obscurin isoform X5
XM_063270113.1 → XP_063126183.1 obscurin isoform X12
XM_063270104.1 → XP_063126174.1 obscurin isoform X1
XM_063270120.1 → XP_063126190.1 obscurin isoform X25

UniProtKB/TrEMBL

A0A0G2JUP3
XM_063270119.1 → XP_063126189.1 obscurin isoform X25

UniProtKB/TrEMBL

A0A0G2JUP3
XM_063270122.1 → XP_063126192.1 obscurin isoform X27

UniProtKB/TrEMBL

A0A0G2JUP3
XM_063270121.1 → XP_063126191.1 obscurin isoform X26

UniProtKB/TrEMBL

A0A0G2JUP3

Related

ENSRNOP00000069172.3, ENSRNOT00000084697.3