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    nish-1 PX domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177981, updated on 14-Nov-2024

    Summary

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    Official Symbol
    nish-1
    Official Full Name
    PX domain-containing protein
    Primary source
    WormBase:WBGene00008750
    Locus tag
    CELE_F13E9.1
    See related
    AllianceGenome:WB:WBGene00008750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nish-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (10864331..10873635)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Histidine--tRNA ligase Neighboring gene Pre-mRNA-splicing factor RBM22 Neighboring gene Transmembrane protein Neighboring gene Neuropeptide-Like Protein Neighboring gene FIP (Fungus-Induced Protein) Related

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rilmenidine extends lifespan and healthspan in Caenorhabditis elegans via a nischarin I1-imidazoline receptor. Bennett DF, et al. Aging Cell, 2023 Feb. PMID 36670049, Free PMC Article
    2. Conserved RNA-binding proteins required for dendrite morphogenesis in Caenorhabditis elegans sensory neurons. Antonacci S, et al. G3 (Bethesda), 2015 Feb 10. PMID 25673135, Free PMC Article
    3. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PX domain-containing protein
    NP_502016.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10864331..10873635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069615.6 → NP_502016.2  PX domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502016.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      K8F807
      Conserved Domains (3) summary
      COG4886
      Location:289 → 423
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:291 → 313
      LRR_RI; leucine-rich repeat [structural motif]
      cl02563
      Location:18 → 137
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    Nucleotide Protein
    Heading Accession and Version

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