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    haf-4 ABC-type antigen peptide transporter [ Caenorhabditis elegans ]

    Gene ID: 171639, updated on 9-Dec-2024

    Summary

    Official Symbol
    haf-4
    Official Full Name
    ABC-type antigen peptide transporter
    Primary source
    WormBase:WBGene00001814
    Locus tag
    CELE_W04C9.1
    See related
    AllianceGenome:WB:WBGene00001814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in lipid metabolic process and lysosomal transport. Located in lysosomal membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; autoimmune disease (multiple); bronchial disease (multiple); diffuse scleroderma; and lung disease (multiple). Orthologous to several human genes including ABCB9 (ATP binding cassette subfamily B member 9). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See haf-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    10
    Sequence:
    Chromosome: I; NC_003279.8 (489969..496158)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein Neighboring gene MICOS complex subunit MIC13 Neighboring gene Transmembrane protein Neighboring gene Dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene P-granule-associated protein deps-1 Neighboring gene Transmembrane protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptide transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ABC-type antigen peptide transporter
    NP_001021666.1
    • Confirmed by transcript evidence
    NP_001293184.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      489969..496158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026495.5NP_001021666.1  ABC-type antigen peptide transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TZD9
      Conserved Domains (3) summary
      cd03249
      Location:498735
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      TIGR00958
      Location:16732
      3a01208; Conjugate Transporter-2 (CT2) Family protein
      pfam00664
      Location:189449
      ABC_membrane; ABC transporter transmembrane region
    2. NM_001306255.3NP_001293184.1  ABC-type antigen peptide transporter [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293184.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLE7
      Conserved Domains (1) summary
      TIGR00958
      Location:1666
      3a01208; Conjugate Transporter-2 (CT2) Family protein