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    acly-1 putative ATP-citrate synthase [ Caenorhabditis elegans ]

    Gene ID: 180485, updated on 2-Nov-2024

    Summary

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    Official Symbol
    acly-1
    Official Full Name
    putative ATP-citrate synthase
    Primary source
    WormBase:WBGene00016995
    Locus tag
    CELE_D1005.1
    See related
    AllianceGenome:WB:WBGene00016995
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and fatty acid biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See acly-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (1479542..1484087)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Signal peptide-containing protein Neighboring gene tRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene C-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NuRD mediates mitochondrial stress-induced longevity via chromatin remodeling in response to acetyl-CoA level. Zhu D, et al. Sci Adv, 2020 Jul. PMID 32789178, Free PMC Article
    2. KIN-4/MAST kinase promotes PTEN-mediated longevity of Caenorhabditis elegans via binding through a PDZ domain. An SWA, et al. Aging Cell, 2019 Jun. PMID 30773781, Free PMC Article
    3. Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids. Möller S, et al. Aging (Albany NY), 2020 Jul 7. PMID 32634117, Free PMC Article
    4. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
    5. C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Reboul J, et al. Nat Genet, 2003 May. PMID 12679813

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP citrate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP citrate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in citrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative ATP-citrate synthase
    NP_508280.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1479542..1484087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075879.6 → NP_508280.1  putative ATP-citrate synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508280.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P53585
      Conserved Domains (7) summary
      cd06100
      Location:856 → 1096
      CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
      PLN02235
      Location:1 → 431
      PLN02235; ATP citrate (pro-S)-lyase
      PLN02522
      Location:492 → 1097
      PLN02522; ATP citrate (pro-S)-lyase
      pfam00549
      Location:660 → 785
      Ligase_CoA; CoA-ligase
      pfam02629
      Location:496 → 600
      CoA_binding; CoA binding domain
      pfam16114
      Location:258 → 432
      Citrate_bind; ATP citrate lyase citrate-binding
      cl17255
      Location:8 → 208
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53585.1

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