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    Lnpk lunapark, ER junction formation factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362151, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lnpkprovided by RGD
    Official Full Name
    lunapark, ER junction formation factorprovided by RGD
    Primary source
    RGD:1312042
    See related
    EnsemblRapid:ENSRNOG00000001593 AllianceGenome:RGD:1312042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lnp
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in endoplasmic reticulum tubular network maintenance and positive regulation of endoplasmic reticulum tubular network organization. Predicted to act upstream of or within blood coagulation; embryonic limb morphogenesis; and regulation of chondrocyte differentiation. Predicted to be located in endoplasmic reticulum tubular network membrane and nucleoplasm. Predicted to be active in endoplasmic reticulum tubular network. Orthologous to human LNPK (lunapark, ER junction formation factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 168.6), Brain (RPKM 92.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lnpk in Genome Data Viewer
    Location:
    3q23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (79826318..79894514, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (59418872..59487029, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (61432128..61494828, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein S7, pseudogene 11 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein S26, pseudogene 2 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A model for the generation and interconversion of ER morphologies. Shemesh T, et al. Proc Natl Acad Sci U S A, 2014 Dec 9. PMID 25404289, Free PMC Article
    2. Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome. Breuss MW, et al. Am J Hum Genet, 2018 Aug 2. PMID 30032983, Free PMC Article
    3. Protein N-myristoylation plays a critical role in the endoplasmic reticulum morphological change induced by overexpression of protein Lunapark, an integral membrane protein of the endoplasmic reticulum. Moriya K, et al. PLoS One, 2013. PMID 24223779, Free PMC Article
    4. Lunapark stabilizes nascent three-way junctions in the endoplasmic reticulum. Chen S, et al. Proc Natl Acad Sci U S A, 2015 Jan 13. PMID 25548161, Free PMC Article
    5. Ulnaless (Ul), a regulatory mutation inducing both loss-of-function and gain-of-function of posterior Hoxd genes. Hérault Y, et al. Development, 1997 Sep. PMID 9342042

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum tubular network maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of endoplasmic reticulum tubular network organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum tubular network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum junction formation protein lunapark
    Names
    limb and neural patterns
    protein lunapark

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077429.2 → NP_001070897.1  endoplasmic reticulum junction formation protein lunapark isoform b

      See identical proteins and their annotated locations for NP_001070897.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JZ33, A0JN29, F7EZG8
      Related
      ENSRNOP00000070893.3, ENSRNOT00000083045.3
      Conserved Domains (2) summary
      PHA03247
      Location:151 → 245
      PHA03247; large tegument protein UL36; Provisional
      pfam10058
      Location:250 → 300
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein

    2. NM_001434300.1 → NP_001421229.1  endoplasmic reticulum junction formation protein lunapark isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AVM8, A6HMC2

    3. NM_001434301.1 → NP_001421230.1  endoplasmic reticulum junction formation protein lunapark isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AVM8, A6HMC2

    4. NM_001434302.1 → NP_001421231.1  endoplasmic reticulum junction formation protein lunapark isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AVM8, A6HMC2

    5. NM_001434303.1 → NP_001421232.1  endoplasmic reticulum junction formation protein lunapark isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AVM8, A6HMC2

    6. NM_001434304.1 → NP_001421233.1  endoplasmic reticulum junction formation protein lunapark isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AVM8, A6HMC2

    7. NM_001434305.1 → NP_001421234.1  endoplasmic reticulum junction formation protein lunapark isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AVM8, A6HMC2

    8. NM_001434306.1 → NP_001421235.1  endoplasmic reticulum junction formation protein lunapark isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AVM8, A6HMC2

    9. NM_001434307.1 → NP_001421236.1  endoplasmic reticulum junction formation protein lunapark isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AVM8, A6HMC2

    10. NM_001434308.1 → NP_001421237.1  endoplasmic reticulum junction formation protein lunapark isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JZ33, A0JN29, F7EZG8

    11. NM_001434309.1 → NP_001421238.1  endoplasmic reticulum junction formation protein lunapark isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JZ33, A0JN29, F7EZG8

    12. NM_001434310.1 → NP_001421239.1  endoplasmic reticulum junction formation protein lunapark isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JZ33, A0JN29, F7EZG8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      79826318..79894514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234385.5 → XP_006234447.1  endoplasmic reticulum junction formation protein lunapark isoform X3

      See identical proteins and their annotated locations for XP_006234447.1

      UniProtKB/TrEMBL
      A0A0G2JZ33, A0JN29, F7EZG8
      Conserved Domains (2) summary
      PHA03247
      Location:151 → 245
      PHA03247; large tegument protein UL36; Provisional
      pfam10058
      Location:250 → 300
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein

    2. XM_063284125.1 → XP_063140195.1  endoplasmic reticulum junction formation protein lunapark isoform X3

    3. XM_063284126.1 → XP_063140196.1  endoplasmic reticulum junction formation protein lunapark isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZ33, A0JN29, F7EZG8

    4. XM_063284127.1 → XP_063140197.1  endoplasmic reticulum junction formation protein lunapark isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZ33, A0JN29, F7EZG8

    5. XM_063284129.1 → XP_063140199.1  endoplasmic reticulum junction formation protein lunapark isoform X3

    6. XM_063284128.1 → XP_063140198.1  endoplasmic reticulum junction formation protein lunapark isoform X3

    7. XM_006234379.5 → XP_006234441.1  endoplasmic reticulum junction formation protein lunapark isoform X1

      Related
      ENSRNOP00000062011.2, ENSRNOT00000068018.4
      Conserved Domains (3) summary
      pfam10058
      Location:250 → 300
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
      cl19878
      Location:19 → 117
      DUF2207; Predicted membrane protein (DUF2207)
      cl22974
      Location:156 → 258
      HpaP; Type III secretion protein (HpaP)

    8. XM_006234377.5 → XP_006234439.1  endoplasmic reticulum junction formation protein lunapark isoform X1

      Conserved Domains (3) summary
      pfam10058
      Location:250 → 300
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
      cl19878
      Location:19 → 117
      DUF2207; Predicted membrane protein (DUF2207)
      cl22974
      Location:156 → 258
      HpaP; Type III secretion protein (HpaP)

    9. XM_006234378.5 → XP_006234440.1  endoplasmic reticulum junction formation protein lunapark isoform X1

      Conserved Domains (3) summary
      pfam10058
      Location:250 → 300
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
      cl19878
      Location:19 → 117
      DUF2207; Predicted membrane protein (DUF2207)
      cl22974
      Location:156 → 258
      HpaP; Type III secretion protein (HpaP)

    10. XM_006234380.5 → XP_006234442.1  endoplasmic reticulum junction formation protein lunapark isoform X1

      Conserved Domains (3) summary
      pfam10058
      Location:250 → 300
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
      cl19878
      Location:19 → 117
      DUF2207; Predicted membrane protein (DUF2207)
      cl22974
      Location:156 → 258
      HpaP; Type III secretion protein (HpaP)

    11. XM_006234382.5 → XP_006234444.1  endoplasmic reticulum junction formation protein lunapark isoform X1

      Conserved Domains (3) summary
      pfam10058
      Location:250 → 300
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
      cl19878
      Location:19 → 117
      DUF2207; Predicted membrane protein (DUF2207)
      cl22974
      Location:156 → 258
      HpaP; Type III secretion protein (HpaP)

    12. XM_006234381.4 → XP_006234443.1  endoplasmic reticulum junction formation protein lunapark isoform X1

      Conserved Domains (3) summary
      pfam10058
      Location:250 → 300
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
      cl19878
      Location:19 → 117
      DUF2207; Predicted membrane protein (DUF2207)
      cl22974
      Location:156 → 258
      HpaP; Type III secretion protein (HpaP)

    13. XM_063284123.1 → XP_063140193.1  endoplasmic reticulum junction formation protein lunapark isoform X1

    14. XM_017591894.3 → XP_017447383.1  endoplasmic reticulum junction formation protein lunapark isoform X1

      Conserved Domains (3) summary
      pfam10058
      Location:250 → 300
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
      cl19878
      Location:19 → 117
      DUF2207; Predicted membrane protein (DUF2207)
      cl22974
      Location:156 → 258
      HpaP; Type III secretion protein (HpaP)

    15. XM_017591895.3 → XP_017447384.1  endoplasmic reticulum junction formation protein lunapark isoform X2

      UniProtKB/TrEMBL
      A0A0G2JZ33
    Nucleotide Protein Strain
    Heading Accession and Version

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