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    let-805 Fibronectin type-III domain-containing protein;SHOCT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175384, updated on 2-Nov-2024

    Summary

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    Official Symbol
    let-805
    Official Full Name
    Fibronectin type-III domain-containing protein;SHOCT domain-containing protein
    Primary source
    WormBase:WBGene00002915
    Locus tag
    CELE_H19M22.2
    See related
    AllianceGenome:WB:WBGene00002915
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cytokine binding activity and cytokine receptor activity. Involved in hemidesmosome assembly. Located in hemidesmosome. Is expressed in hypodermis; pharynx; touch receptor neurons; and uterine seam cell. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and vesicoureteral reflux. Orthologous to human TNXB (tenascin XB). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See let-805 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    29
    Sequence:
    Chromosome: III; NC_003281.10 (2658083..2681112)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene CX domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myotactin, a novel hypodermal protein involved in muscle-cell adhesion in Caenorhabditis elegans. Hresko MC, et al. J Cell Biol, 1999 Aug 9. PMID 10444073, Free PMC Article
    2. Neuron-epidermal attachment protects hyper-fragile axons from mechanical strain. Bonacossa-Pereira I, et al. Cell Rep, 2022 Mar 8. PMID 35263583
    3. A tension-induced mechanotransduction pathway promotes epithelial morphogenesis. Zhang H, et al. Nature, 2011 Mar 3. PMID 21368832
    4. Genetic Suppression of Basement Membrane Defects in Caenorhabditis elegans by Gain of Function in Extracellular Matrix and Cell-Matrix Attachment Genes. Gotenstein JR, et al. Genetics, 2018 Apr. PMID 29440357, Free PMC Article
    5. C. elegans ankyrin repeat protein VAB-19 is a component of epidermal attachment structures and is essential for epidermal morphogenesis. Ding M, et al. Development, 2003 Dec. PMID 14534136

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hemidesmosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in hemidesmosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fibronectin type-III domain-containing protein;SHOCT domain-containing protein
    NP_001022640.1
    • Confirmed by transcript evidence
    NP_001022641.1
    • Confirmed by transcript evidence
    NP_001022643.1
    • Confirmed by transcript evidence
    NP_001293642.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2658083..2681112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027470.3 → NP_001022641.1  Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9UB28
      Conserved Domains (3) summary
      smart00060
      Location:2017 → 2100
      FN3; Fibronectin type 3 domain
      cd00063
      Location:1400 → 1493
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1299 → 1386
      fn3; Fibronectin type III domain

    2. NM_001027469.3 → NP_001022640.1  Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022640.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9UB29
      Conserved Domains (3) summary
      smart00060
      Location:2017 → 2100
      FN3; Fibronectin type 3 domain
      cd00063
      Location:1400 → 1493
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:1299 → 1386
      fn3; Fibronectin type III domain

    3. NM_001027472.5 → NP_001022643.1  Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022643.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0C1
      Conserved Domains (3) summary
      smart00060
      Location:241 → 311
      FN3; Fibronectin type 3 domain
      cd00063
      Location:438 → 530
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:143 → 212
      fn3; Fibronectin type III domain

    4. NM_001306713.4 → NP_001293642.1  SHOCT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BKP3
    Nucleotide Protein
    Heading Accession and Version

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