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    unc-49 Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein [ Caenorhabditis elegans ]

    Gene ID: 176472, updated on 27-Dec-2024

    Summary

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    Official Symbol
    unc-49
    Official Full Name
    Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein
    Primary source
    WormBase:WBGene00006784
    Locus tag
    CELE_T21C12.1
    See related
    AllianceGenome:WB:WBGene00006784
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GABA-A receptor activity. Predicted to contribute to chloride channel activity. Involved in gamma-aminobutyric acid signaling pathway; locomotory behavior; and regulation of backward locomotion. Located in neuromuscular junction and postsynaptic membrane. Is expressed in AVA; anal sphincter muscle; body wall musculature; and somatic nervous system. Used to study epilepsy. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-49 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    26
    Sequence:
    Chromosome: III; NC_003281.10 (10520762..10532705)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Sec1 family domain-containing protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 4-hydroxyphenylpyruvate dioxygenase Neighboring gene ncRNA Neighboring gene Neuropeptide-like protein 68

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of epilepsy-associated GABA(A) receptor mutations using Caenorhabditis elegans. Gadhia A, et al. Epilepsia Open, 2024 Aug. PMID 38813985, Free PMC Article
    2. The composition of the GABA receptor at the Caenorhabditis elegans neuromuscular junction. Bamber BA, et al. Br J Pharmacol, 2005 Feb. PMID 15655525, Free PMC Article
    3. Residues in the first transmembrane domain of the Caenorhabditis elegans GABA(A) receptor confer sensitivity to the neurosteroid pregnenolone sulfate. Wardell B, et al. Br J Pharmacol, 2006 May. PMID 16547524, Free PMC Article
    4. The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. Twede V, et al. Mol Pharmacol, 2007 Nov. PMID 17715402
    5. Pharmacological characterization of the homomeric and heteromeric UNC-49 GABA receptors in C. elegans. Bamber BA, et al. Br J Pharmacol, 2003 Mar. PMID 12642390, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UNC-49 is a redox-sensitive GABAA receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.
      Title: UNC-49 is a redox-sensitive GABA(A) receptor that regulates the mitochondrial unfolded protein response cell nonautonomously.
    2. GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans.
      Title: GABAergic synapses suppress intestinal innate immunity via insulin signaling in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of backward locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gamma-aminobutyric acid receptor subunit beta;Neur_chan_memb domain-containing protein;Neurotransmitter-gated ion-channel ligand-binding domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein;Uncharacterized protein
    NP_001022783.1
    • Partially confirmed by transcript evidence
    NP_001022784.1
    • Partially confirmed by transcript evidence
    NP_001022785.1
    • Partially confirmed by transcript evidence
    NP_001022786.1
    • Confirmed by transcript evidence
    NP_001076648.1
    • Confirmed by transcript evidence
    NP_001293662.1
    • Partially confirmed by transcript evidence
    NP_001293663.1
    • Confirmed by transcript evidence
    NP_001368253.1
    • Confirmed by transcript evidence
    NP_001368254.1
    • Partially confirmed by transcript evidence
    NP_001370908.1
    • Confirmed by transcript evidence
    NP_001379283.1
    • Confirmed by transcript evidence
    NP_001379457.1
    • Confirmed by transcript evidence
    NP_001380139.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10520762..10532705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027612.4 → NP_001022783.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022783.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEY3
      Conserved Domains (3) summary
      TIGR00860
      Location:37 → 465
      LIC; Cation transporter family protein
      pfam02931
      Location:37 → 248
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:260 → 463
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001027613.3 → NP_001022784.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022784.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFN4
      Conserved Domains (3) summary
      TIGR00860
      Location:37 → 453
      LIC; Cation transporter family protein
      pfam02931
      Location:37 → 248
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:260 → 451
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    3. NM_001027615.4 → NP_001022786.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE10
      Conserved Domains (3) summary
      TIGR00860
      Location:37 → 423
      LIC; Cation transporter family protein
      pfam02931
      Location:37 → 222
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:261 → 421
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    4. NM_001027614.4 → NP_001022785.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECD3
      Conserved Domains (3) summary
      TIGR00860
      Location:37 → 484
      LIC; Cation transporter family protein
      pfam02931
      Location:37 → 248
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:260 → 482
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    5. NM_001392191.1 → NP_001379283.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBQ0
      Conserved Domains (1) summary
      TIGR00860
      Location:37 → 471
      LIC; Cation transporter family protein

    6. NM_001392190.1 → NP_001380139.1  Gamma-aminobutyric acid receptor subunit beta [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBP4
      Conserved Domains (1) summary
      TIGR00860
      Location:37 → 465
      LIC; Cation transporter family protein

    7. NM_001382981.2 → NP_001370908.1  Neurotransmitter-gated ion-channel ligand-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBB4
      Conserved Domains (2) summary
      cd03558
      Location:167 → 181
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:60 → 187
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    8. NM_001306734.3 → NP_001293663.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293663.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBC0
      Conserved Domains (2) summary
      pfam02931
      Location:1 → 54
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:93 → 253
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    9. NM_001379902.1 → NP_001368254.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRE0
      Conserved Domains (1) summary
      TIGR00860
      Location:1 → 297
      LIC; Cation transporter family protein

    10. NM_001379903.1 → NP_001368253.1  Neur_chan_memb domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PM48
      Conserved Domains (1) summary
      TIGR00860
      Location:1 → 303
      LIC; Cation transporter family protein

    11. NM_001306733.3 → NP_001293662.1  Uncharacterized protein CELE_T21C12.1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PEJ2
      Conserved Domains (1) summary
      pfam02932
      Location:36 → 56
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    12. NM_001392193.1 → NP_001379457.1  Neurotransmitter-gated ion-channel transmembrane domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDM9
      Conserved Domains (2) summary
      TIGR00860
      Location:3 → 239
      LIC; Cation transporter family protein
      cd19049
      Location:72 → 237
      LGIC_TM_anion; transmembrane domain of anionic Cys-loop neurotransmitter-gated ion channels, includes GABAAR, GlyR and GluCl

    13. NM_001083179.4 → NP_001076648.1  Neurotransmitter-gated ion-channel transmembrane domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076648.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0PDK2
      Conserved Domains (2) summary
      cd03559
      Location:24 → 105
      LGIC_TM; TM3 helix [structural motif]
      cl38911
      Location:1 → 130
      LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels
    Nucleotide Protein
    Heading Accession and Version

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