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    mtx-2 Metaxin-2 homolog [ Caenorhabditis elegans ]

    Gene ID: 176087, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtx-2
    Official Full Name
    Metaxin-2 homolog
    Primary source
    WormBase:WBGene00022516
    Locus tag
    CELE_ZC97.1
    See related
    AllianceGenome:WB:WBGene00022516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in mitochondrion organization. Located in mitochondrion. Orthologous to human MTX2 (metaxin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mtx-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (7761977..7763603, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Cadherin-3 Neighboring gene ncRNA Neighboring gene Putative serine protease pcp-1 Neighboring gene Putative ATP-dependent RNA helicase ZK686.2 Neighboring gene Putative zinc finger protein ZK686.5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metaxins are core components of mitochondrial transport adaptor complexes. Zhao Y, et al. Nat Commun, 2021 Jan 4. PMID 33397950, Free PMC Article
    2. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
    4. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metaxins are core components of mitochondrial transport adaptor complexes.
      Title: Metaxins are core components of mitochondrial transport adaptor complexes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Metaxin-2 homolog
    NP_498689.2
    • Confirmed by transcript evidence
    NP_871672.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7761977..7763603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066288.7 → NP_498689.2  Metaxin-2 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498689.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E9P839, P34599, Q2PWT9, Q8I7F3
      Conserved Domains (2) summary
      cd03079
      Location:26 → 99
      GST_N_Metaxin2; GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer ...
      cl02776
      Location:129 → 254
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    2. NM_181943.7 → NP_871672.2  Metaxin-2 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871672.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34599
      Conserved Domains (1) summary
      cl00388
      Location:26 → 66
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

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