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    mfsd-6 Major facilitator superfamily associated domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176073, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mfsd-6
    Official Full Name
    Major facilitator superfamily associated domain-containing protein
    Primary source
    WormBase:WBGene00020051
    Locus tag
    CELE_R13A5.9
    See related
    AllianceGenome:WB:WBGene00020051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Acts upstream of or within with a positive effect on synaptic vesicle exocytosis. Located in synaptic vesicle. Is expressed in intestine and nervous system. Orthologous to human MFSD6 (major facilitator superfamily domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mfsd-6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (7575284..7579411, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Pescadillo homolog Neighboring gene CMP/dCMP-type deaminase domain-containing protein Neighboring gene Polycystin cation channel PKD1/PKD2 domain-containing protein Neighboring gene Serpentine receptor class gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Caenorhabditis elegans R13A5.9 gene plays a role in synaptic vesicle exocytosis. Ogurusu T, et al. Biochem Biophys Res Commun, 2015 Aug 7. PMID 26079877
    2. Gene Function Prediction Based on Developmental Transcriptomes of the Two Sexes in C. elegans. Kim B, et al. Cell Rep, 2016 Oct 11. PMID 27732864, Free PMC Article
    3. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration. Kim KW, et al. Elife, 2018 Nov 21. PMID 30461420, Free PMC Article
    4. Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in Caenorhabditis elegans. McCulloch KA, et al. G3 (Bethesda), 2017 Jul 5. PMID 28468816, Free PMC Article
    5. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Major facilitator superfamily associated domain-containing protein
    NP_498662.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7575284..7579411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066261.6 → NP_498662.1  Major facilitator superfamily associated domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498662.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y88
      Conserved Domains (1) summary
      cd17335
      Location:23 → 560
      MFS_MFSD6; Major facilitator superfamily domain-containing protein 6
    Nucleotide Protein
    Heading Accession and Version

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