lpd-7 Pescadillo homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lpd-7
Official Full Name: Pescadillo homolog
Primary source: WormBase:WBGene00003063
Locus tag: CELE_R13A5.12
See related: AllianceGenome:WB:WBGene00003063
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity. Involved in lipid storage. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of PeBoW complex. Orthologous to human PES1 (pescadillo ribosomal biogenesis factor 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lpd-7 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (7573350..7575263)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13A5.13 (e-PCR)
- UniSTS:311599

R13A5.12 (e-PCR)
- UniSTS:317519

R13A5.8 (e-PCR)
- UniSTS:317009

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PeBoW complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Pescadillo homolog

NP_498661.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7573350..7575263

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066260.7 → NP_498661.1 Pescadillo homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498661.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95Y89

Conserved Domains (3) summary

COG5163
Location:4 → 514

NOP7; Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]

pfam06732
Location:9 → 252

Pescadillo_N; Pescadillo N-terminus

cl00038
Location:315 → 397

BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...