ceh-13 Homeobox protein ceh-13 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ceh-13
Official Full Name: Homeobox protein ceh-13
Primary source: WormBase:WBGene00000437
Locus tag: CELE_R13A5.5
See related: AllianceGenome:WB:WBGene00000437
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA-binding transcription factor activity. Involved in cell-cell adhesion and embryo development. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic cell; hypodermal cell; neurons; somatic nervous system; and in male. Human ortholog(s) of this gene implicated in Athabaskan brainstem dysgenesis syndrome and autistic disorder. Orthologous to several human genes including HOXB1 (homeobox B1) and HOXD1 (homeobox D1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ceh-13 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (7555660..7558041)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cnd-1/NeuroD1 Functions with the Homeobox Gene ceh-5/Vax2 and Hox Gene ceh-13/labial To Specify Aspects of RME and DD Neuron Fate in Caenorhabditis elegans.
Title: cnd-1/NeuroD1 Functions with the Homeobox Gene ceh-5/Vax2 and Hox Gene ceh-13/labial To Specify Aspects of RME and DD Neuron Fate in Caenorhabditis elegans.
Unlike other Hox genes which display region-specific accumulation and function along the A-P axis, the expression of ceh-13 extends beyond the anterior region; results suggest that middle-group Hox genes emerged from a ceh-13-like primordial Hox ancestor.
Title: The C. elegans Hox gene ceh-13 regulates cell migration and fusion in a non-colinear way. Implications for the early evolution of Hox clusters.
ceh-13, the labial orthologue in Caenorhabditis elegans, is expressed both during embryogenesis and post- embryonic development.
Title: Expression of the C. elegans labial orthologue ceh-13 during male tail morphogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R13A5.5 (e-PCR)
- UniSTS:317008

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Homeobox protein ceh-13

NP_498655.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7555660..7558041

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066254.8 → NP_498655.1 Homeobox protein ceh-13 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498655.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P17488

Conserved Domains (1) summary

pfam00046
Location:118 → 164

Homeobox; Homeobox domain