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    tol-1 TIR domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171635, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tol-1
    Official Full Name
    TIR domain-containing protein
    Primary source
    WormBase:WBGene00006593
    Locus tag
    CELE_C07F11.1
    See related
    AllianceGenome:WB:WBGene00006593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable signaling receptor activity. Involved in defense response to Gram-negative bacterium and embryo development. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in neurons. Orthologous to several human genes including TRIL (TLR4 interactor with leucine rich repeats); CHAD (chondroadherin); and CHADL (chondroadherin like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tol-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    14
    Sequence:
    Chromosome: I; NC_003279.8 (444003..461605)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ubiquitinyl hydrolase 1 Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene GTP-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A secreted bacterial peptidoglycan hydrolase enhances tolerance to enteric pathogens. Rangan KJ, et al. Science, 2016 Sep 23. PMID 27708039, Free PMC Article
    2. Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior. Brandt JP, et al. Curr Biol, 2015 Aug 31. PMID 26279230, Free PMC Article
    3. Effect of Caenorhabditis elegans age and genotype on horizontal gene transfer in intestinal bacteria. Portal-Celhay C, et al. FASEB J, 2013 Feb. PMID 23085995, Free PMC Article
    4. A transcriptomic insight into the infective juvenile stage of the insect parasitic nematode, Heterorhabditis indica. Somvanshi VS, et al. BMC Genomics, 2016 Mar 1. PMID 26931371, Free PMC Article
    5. Studying host-pathogen interactions and innate immunity in Caenorhabditis elegans. Kim D. Dis Model Mech, 2008 Nov-Dec. PMID 19093025, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that pathologies in tol-1(-) mutant nematodes are indistinguishable from wild type animals, indicating that nematodes do not employ this orthologue for detection of Coxiella burnetii
      Title: Analysis of the Caenorhabditis elegans innate immune response to Coxiella burnetii.
    2. For pathogen avoidance TOL-1 signaling is required in the chemosensory BAG neurons, where it regulates gene expression and is necessary for their chemosensory function. TOL-1 acts together with many conserved components of TLR signaling.
      Title: Toll-like Receptor Signaling Promotes Development and Function of Sensory Neurons Required for a C. elegans Pathogen-Avoidance Behavior.
    3. The results indicate that TOL-1 has a direct role in defence response to certain Gram-negative bacteria and indicate that part of the TLR-mediated immunity might be evolutionarily conserved.
      Title: A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TIR domain-containing protein
    NP_001020983.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      444003..461605
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025812.6 → NP_001020983.1  TIR domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001020983.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BIW9, Q9N5Z3
      Conserved Domains (6) summary
      COG4886
      Location:265 → 600
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:786 → 809
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:307 → 331
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:785 → 844
      LRR_8; Leucine rich repeat
      pfam14580
      Location:806 → 890
      LRR_9; Leucine-rich repeat
      cl23749
      Location:1056 → 1194
      TIR_2; TIR domain
    Nucleotide Protein
    Heading Accession and Version

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