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    eel-1 HECT-type E3 ubiquitin transferase [ Caenorhabditis elegans ]

    Gene ID: 177084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eel-1
    Official Full Name
    HECT-type E3 ubiquitin transferase
    Primary source
    WormBase:WBGene00022069
    Locus tag
    CELE_Y67D8C.5
    See related
    AllianceGenome:WB:WBGene00022069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; hemidesmosome assembly; and signal transduction in response to DNA damage. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hermaphrodite gonad; intestine; neurons; pharynx; and vulva. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eel-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    15
    Sequence:
    Chromosome: IV; NC_003282.8 (3032713..3050104, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Helix-loop-helix protein lin-22 Neighboring gene Protein NDNF C-terminal domain-containing protein Neighboring gene pseudo Neighboring gene Inappropriate Vulval cell Proliferation Homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans. Suthakaran N, et al. PLoS One, 2021. PMID 34797853, Free PMC Article
    2. The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development. Opperman KJ, et al. Cell Rep, 2017 Apr 25. PMID 28445732, Free PMC Article
    3. MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity. Xie J, et al. PLoS Genet, 2023 Sep. PMID 37729192, Free PMC Article
    4. Improved CRISPR/Cas9 knock-in efficiency via the self-excising cassette (SEC) selection method in C. elegans. Huang G, et al. MicroPubl Biol, 2021. PMID 34549176, Free PMC Article
    5. The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans. Ross AJ, et al. Cell Death Differ, 2011 Jul. PMID 21233842, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
      Title: O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 modulate seizure susceptibility in C. elegans.
    2. findings demonstrate that OGT-1 and EEL-1 form a conserved signaling complex and function together to affect GABA neuron function
      Title: A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function.
    3. EEL-1 functions as the RING family ubiquitin ligase RPM-1 to regulate synapse formation and axon termination.
      Title: The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development.
    4. EEL-1 fine-tunes DNA damageinduced apoptosis signalling in the C. elegans germline.
      Title: The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans.
    5. EEL-1 fine tunes by 2-fold the abundance of myotactin, the putative hemidesmosome extracellular matrix receptor.
      Title: CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asymmetric protein localization involved in cell fate determination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in hemidesmosome assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HECT-type E3 ubiquitin transferase
    NP_001294466.1
    • Partially confirmed by transcript evidence
    NP_001294467.1
    • Partially confirmed by transcript evidence
    NP_001294468.1
    • Partially confirmed by transcript evidence
    NP_001294469.1
    • Partially confirmed by transcript evidence
    NP_001294470.1
    • Partially confirmed by transcript evidence
    NP_001294471.1
    • Partially confirmed by transcript evidence
    NP_001294472.1
    • Partially confirmed by transcript evidence
    NP_500284.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3032713..3050104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067883.5 → NP_500284.2  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500284.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GUP2
      Conserved Domains (7) summary
      smart00119
      Location:3846 → 4174
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3822 → 4175
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14306
      Location:1440 → 1474
      UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
      pfam06012
      Location:95 → 374
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:571 → 934
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2978 → 3115
      DUF4414; Domain of unknown function (DUF4414)
      cl02729
      Location:1785 → 1844
      WWE; WWE domain

    2. NM_001307542.3 → NP_001294471.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBK1
      Conserved Domains (7) summary
      smart00119
      Location:3852 → 4180
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3828 → 4181
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14306
      Location:1440 → 1474
      UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
      pfam06012
      Location:95 → 374
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:571 → 934
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2981 → 3118
      DUF4414; Domain of unknown function (DUF4414)
      cl02729
      Location:1785 → 1844
      WWE; WWE domain

    3. NM_001307538.3 → NP_001294467.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294467.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBX5
      Conserved Domains (7) summary
      smart00119
      Location:3849 → 4177
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3825 → 4178
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14306
      Location:1440 → 1474
      UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
      pfam06012
      Location:95 → 374
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:571 → 934
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2981 → 3118
      DUF4414; Domain of unknown function (DUF4414)
      cl02729
      Location:1785 → 1844
      WWE; WWE domain

    4. NM_001307540.3 → NP_001294469.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294469.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRN6
      Conserved Domains (7) summary
      smart00119
      Location:3849 → 4177
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3825 → 4178
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14306
      Location:1440 → 1474
      UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
      pfam06012
      Location:95 → 374
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:571 → 934
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2978 → 3115
      DUF4414; Domain of unknown function (DUF4414)
      cl02729
      Location:1785 → 1844
      WWE; WWE domain

    5. NM_001307537.4 → NP_001294466.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294466.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBJ5
      Conserved Domains (7) summary
      smart00119
      Location:3848 → 4176
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3824 → 4177
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14306
      Location:1442 → 1476
      UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
      pfam06012
      Location:95 → 376
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:573 → 936
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2980 → 3117
      DUF4414; Domain of unknown function (DUF4414)
      cl02729
      Location:1787 → 1846
      WWE; WWE domain

    6. NM_001307541.3 → NP_001294470.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PES6
      Conserved Domains (7) summary
      smart00119
      Location:3851 → 4179
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3827 → 4180
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14306
      Location:1442 → 1476
      UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
      pfam06012
      Location:95 → 376
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:573 → 936
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2980 → 3117
      DUF4414; Domain of unknown function (DUF4414)
      cl02729
      Location:1787 → 1846
      WWE; WWE domain

    7. NM_001307539.4 → NP_001294468.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294468.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PMD1
      Conserved Domains (7) summary
      smart00119
      Location:3851 → 4179
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3827 → 4180
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14306
      Location:1442 → 1476
      UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
      pfam06012
      Location:95 → 376
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:573 → 936
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2983 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      cl02729
      Location:1787 → 1846
      WWE; WWE domain

    8. NM_001307543.4 → NP_001294472.1  HECT-type E3 ubiquitin transferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294472.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBY0
      Conserved Domains (7) summary
      smart00119
      Location:3854 → 4182
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:3830 → 4183
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14306
      Location:1442 → 1476
      UBA_VP13D; UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins
      pfam06012
      Location:95 → 376
      DUF908; Domain of Unknown Function (DUF908)
      pfam06025
      Location:573 → 936
      DUF913; Domain of Unknown Function (DUF913)
      pfam14377
      Location:2983 → 3120
      DUF4414; Domain of unknown function (DUF4414)
      cl02729
      Location:1787 → 1846
      WWE; WWE domain
    Nucleotide Protein
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