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    Y54G2A.18 Endoplasmic reticulum transmembrane protein [ Caenorhabditis elegans ]

    Gene ID: 177072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y54G2A.18
    Official Full Name
    Endoplasmic reticulum transmembrane protein
    Primary source
    WormBase:WBGene00021883
    Locus tag
    CELE_Y54G2A.18
    See related
    AllianceGenome:WB:WBGene00021883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Acts upstream of or within IRE1-mediated unfolded protein response. Located in membrane raft. Is expressed in anal depressor muscle; body wall musculature; excretory cell; intestine; and reproductive system. Human ortholog(s) of this gene implicated in deafness, dystonia, and cerebral hypomyelination and sensorineural hearing loss. Orthologous to several human genes including BCAP29 (B cell receptor associated protein 29). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y54G2A.18 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (2891560..2892495, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nicotinate phosphoribosyltransferase Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Thioredoxin-like protein Neighboring gene Intraflagellar transport protein 46 homolog Neighboring gene pseudo Neighboring gene EB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An analysis of the Caenorhabditis elegans lipid raft proteome using geLC-MS/MS. Rao W, et al. J Proteomics, 2011 Feb 1. PMID 21070894
    2. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to endoplasmic reticulum exit site IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft HDA PubMed 

    General protein information

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    Preferred Names
    Endoplasmic reticulum transmembrane protein
    NP_500267.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2891560..2892495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067866.8 → NP_500267.1  Endoplasmic reticulum transmembrane protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBI0
      Conserved Domains (1) summary
      pfam05529
      Location:1 → 194
      Bap31; B-cell receptor-associated protein 31-like
    Nucleotide Protein
    Heading Accession and Version

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