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    daf-25 Dauer abnormal formation protein 25 [ Caenorhabditis elegans ]

    Gene ID: 171623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    daf-25
    Official Full Name
    Dauer abnormal formation protein 25
    Primary source
    WormBase:WBGene00000917
    Locus tag
    CELE_Y48G1A.3
    See related
    AllianceGenome:WB:WBGene00000917
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Involved in several processes, including dauer exit; positive regulation of cGMP-mediated signaling; and protein localization to cell periphery. Located in non-motile cilium. Is expressed in intestine and sensory neurons. Orthologous to human ANKMY2 (ankyrin repeat and MYND domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See daf-25 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (332604..337845)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Exportin-2;Exportin-2 C-terminal domain-containing protein Neighboring gene Nucleolar protein 14 Neighboring gene Malignant brain tumor repeat protein 1 Neighboring gene Transposase Neighboring gene BTB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influence of environmental temperature on mouth-form plasticity in Pristionchus pacificus acts through daf-11-dependent cGMP signaling. Lenuzzi M, et al. J Exp Zool B Mol Dev Evol, 2023 Mar. PMID 34379868
    2. A novel zf-MYND protein, CHB-3, mediates guanylyl cyclase localization to sensory cilia and controls body size of Caenorhabditis elegans. Fujiwara M, et al. PLoS Genet, 2010 Nov 24. PMID 21124861, Free PMC Article
    3. Distinct functional constraints partition sequence conservation in a cis-regulatory element. Barrière A, et al. PLoS Genet, 2011 Jun. PMID 21655084, Free PMC Article
    4. Ciliary Tip Signaling Compartment Is Formed and Maintained by Intraflagellar Transport. van der Burght SN, et al. Curr Biol, 2020 Nov 2. PMID 32916106
    5. Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. Jensen VL, et al. PLoS Genet, 2010 Nov 24. PMID 21124868, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dauer exit IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cGMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to microvillus membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor localization to non-motile cilium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to temperature stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in non-motile cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dauer abnormal formation protein 25
    NP_490719.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      332604..337845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058318.5 → NP_490719.1  Dauer abnormal formation protein 25 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490719.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9N3Q8
      Conserved Domains (4) summary
      cd00204
      Location:9 → 127
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01753
      Location:321 → 357
      zf-MYND; MYND finger
      pfam12796
      Location:12 → 105
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:10 → 38
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9N3Q8.2

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