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    Cmtm8 CKLF-like MARVEL transmembrane domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301045, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cmtm8provided by RGD
    Official Full Name
    CKLF-like MARVEL transmembrane domain containing 8provided by RGD
    Primary source
    RGD:735040
    See related
    EnsemblRapid:ENSRNOG00000011201 AllianceGenome:RGD:735040
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cklfsf8
    Summary
    Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in nucleoplasm. Predicted to be active in membrane. Orthologous to human CMTM8 (CKLF like MARVEL transmembrane domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 88.1), Lung (RPKM 87.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cmtm8 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (123360168..123425291, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (114481730..114547107, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (122848249..122913597, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene CKLF-like MARVEL transmembrane domain containing 6 Neighboring gene CKLF-like MARVEL transmembrane domain containing 7 Neighboring gene uncharacterized LOC134480243 Neighboring gene U6 spliceosomal RNA Neighboring gene glycerol-3-phosphate dehydrogenase 1 like Neighboring gene oxysterol binding protein-like 10 Neighboring gene uncharacterized LOC108351789

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. Han W, et al. Genomics, 2003 Jun. PMID 12782130
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108531

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of myelin sheath IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CKLF-like MARVEL transmembrane domain-containing protein 8
    Names
    chemokine-like factor super family 8
    chemokine-like related protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198754.2 → NP_942049.1  CKLF-like MARVEL transmembrane domain-containing protein 8

      See identical proteins and their annotated locations for NP_942049.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088094
      UniProtKB/TrEMBL
      F7F866, Q71B06
      Related
      ENSRNOP00000015188.4, ENSRNOT00000015188.6
      Conserved Domains (1) summary
      pfam01284
      Location:36 → 162
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      123360168..123425291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265301.1 → XP_063121371.1  CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X3

    2. XM_006243964.5 → XP_006244026.1  CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7X1
      Related
      ENSRNOP00000077565.1, ENSRNOT00000101305.2
      Conserved Domains (1) summary
      pfam01284
      Location:44 → 156
      MARVEL; Membrane-associating domain

    3. XM_063265300.1 → XP_063121370.1  CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X2

    4. XM_063265302.1 → XP_063121372.1  CKLF-like MARVEL transmembrane domain-containing protein 8 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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