Zfp105 zinc finger protein 105 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp105provided by RGD
Official Full Name: zinc finger protein 105provided by RGD
Primary source: RGD:1309905
See related: EnsemblRapid:ENSRNOG00000079667 AllianceGenome:RGD:1309905
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cellular response to retinoic acid; regulation of transcription by RNA polymerase II; and spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to human ZNF35 (zinc finger protein 35). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 86.6), Kidney (RPKM 81.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (131444692..131456159)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (122567229..122578696)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (131998787..132009987)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

RH128432 (e-PCR)
- UniSTS:211740

UniSTS:496746 (e-PCR)
- UniSTS:496746

Zfp105 (e-PCR), detects polymorphism
- UniSTS:496746

RH129682 (e-PCR)
- UniSTS:212979

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012128.2 → NP_001012128.1 zinc finger protein 35

See identical proteins and their annotated locations for NP_001012128.1

Status: VALIDATED

Source sequence(s)

BC088185, DY310202

UniProtKB/TrEMBL

F7FKJ4, Q5M881

Related

ENSRNOP00000109569.1, ENSRNOT00000168577.1

Conserved Domains (4) summary

COG5048
Location:186 → 366

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:333 → 353

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:331 → 353

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:373 → 398

zf-H2C2_2; Zinc-finger double domain