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    him-5 High Incidence of Males (increased X chromosome loss) [ Caenorhabditis elegans ]

    Gene ID: 183932, updated on 9-Dec-2024

    Summary

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    Official Symbol
    him-5
    Official Full Name
    High Incidence of Males (increased X chromosome loss)
    Primary source
    WormBase:WBGene00001864
    Locus tag
    CELE_D1086.4
    See related
    AllianceGenome:WB:WBGene00001864
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in meiotic DNA double-strand break formation involved in reciprocal meiotic recombination and meiotic chromosome segregation. Located in condensed chromosome. Is expressed in gonad. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See him-5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    7
    Sequence:
    Chromosome: V; NC_003283.11 (14090426..14092454)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene DUF19 domain-containing protein Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crossover distribution and frequency are regulated by him-5 in Caenorhabditis elegans. Meneely PM, et al. Genetics, 2012 Apr. PMID 22267496, Free PMC Article
    2. The proximate determinants of sex ratio in C. elegans populations. Cutter AD, et al. Genet Res, 2003 Apr. PMID 12872911
    3. Posttranslational insertion of a membrane protein on Caenorhabditis elegans sperm occurs without de novo protein synthesis. Pavalko FM, et al. J Cell Biochem, 1989 Oct. PMID 2613747
    4. Relationship between plasma membrane mobility and substrate attachment in the crawling movement of spermatozoa from Caenorhabditis elegans. Pavalko FM, et al. Cell Motil Cytoskeleton, 1988. PMID 3208296
    5. Fast and easy method to culture and obtain large populations of male nematodes. Cailloce J, et al. MethodsX, 2023 Dec. PMID 37539340, Free PMC Article

    See all (135) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. rec-1; him-5 double mutants are synthetic-lethal due to a defect in meiotic double-strand break formation
      Title: REC-1 and HIM-5 distribute meiotic crossovers and function redundantly in meiotic double-strand break formation in Caenorhabditis elegans.
    2. him-5 is suppressed by changes in X chromosome architecture.
      Title: Crossover distribution and frequency are regulated by him-5 in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic DNA double-strand break formation involved in reciprocal meiotic recombination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in meiotic chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in condensed chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    High Incidence of Males (increased X chromosome loss)
    NP_001256555.1
    • Product from WormBase gene class him;
      Confirmed by transcript evidence
    NP_001256556.1
    • Product from WormBase gene class him;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14090426..14092454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001269626.2 → NP_001256555.1  High Incidence of Males (increased X chromosome loss) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256555.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17724

    2. NM_001269627.3 → NP_001256556.1  High Incidence of Males (increased X chromosome loss) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1B6V2
    Nucleotide Protein
    Heading Accession and Version

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