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    ent-2 Equilibrative nucleoside transporter 3 [ Caenorhabditis elegans ]

    Gene ID: 181648, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ent-2
    Official Full Name
    Equilibrative nucleoside transporter 3
    Primary source
    WormBase:WBGene00010701
    Locus tag
    CELE_K09A9.3
    See related
    AllianceGenome:WB:WBGene00010701
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nucleoside transmembrane transporter activity. Predicted to be involved in nucleoside transmembrane transport. Located in plasma membrane. Is expressed in intestine; isthmus; metacorpus; procorpus; and terminal bulb. Human ortholog(s) of this gene implicated in histiocytosis-lymphadenopathy plus syndrome. Orthologous to human SLC29A2 (solute carrier family 29 member 2) and SLC29A3 (solute carrier family 29 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ent-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (15601067..15603686)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Ras-related protein Rab-14 Neighboring gene Protein nipi-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional redundancy of two nucleoside transporters of the ENT family (CeENT1, CeENT2) required for development of Caenorhabditis elegans. Appleford PJ, et al. Mol Membr Biol, 2004 Jul-Aug. PMID 15371014
    2. Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters. Visser F, et al. J Biol Chem, 2005 Mar 25. PMID 15649894
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nucleoside transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleoside transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Equilibrative nucleoside transporter 3
    NP_510571.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15601067..15603686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078170.7 → NP_510571.1  Equilibrative nucleoside transporter 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510571.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93871
      Conserved Domains (1) summary
      cl15430
      Location:156 → 446
      Nucleoside_tran; Nucleoside transporter
    Nucleotide Protein
    Heading Accession and Version

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