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    spdl-1 Spindly-like protein spdl-1 [ Caenorhabditis elegans ]

    Gene ID: 174256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    spdl-1
    Official Full Name
    Spindly-like protein spdl-1
    Primary source
    WormBase:WBGene00015515
    Locus tag
    CELE_C06A8.5
    See related
    AllianceGenome:WB:WBGene00015515
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including nuclear chromosome segregation; positive regulation of kinetochore assembly; and regulation of chromosome segregation. Located in kinetochore and microtubule. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See spdl-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (7781566..7783351)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene U2A'/phosphoprotein 32 family A C-terminal domain-containing protein Neighboring gene putative methylenetetrahydrofolate reductase (NADPH) Neighboring gene snRNA-activating protein complex subunit 1 Neighboring gene Skp1-related protein Neighboring gene GLutamate Receptor family (AMPA) Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly. Gama JB, et al. J Cell Biol, 2017 Apr 3. PMID 28320824, Free PMC Article
    2. Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation. Cheerambathur DK, et al. Science, 2013 Dec 6. PMID 24231804, Free PMC Article
    3. SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans. Yamamoto TG, et al. J Cell Biol, 2008 Oct 20. PMID 18936247, Free PMC Article
    4. Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly. Chan YW, et al. J Cell Biol, 2009 Jun 1. PMID 19468067, Free PMC Article
    5. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Gassmann R, et al. Genes Dev, 2008 Sep 1. PMID 18765790, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the RZZ complex can inhibit the formation of load-bearing attachments and that this activity of the RZZ complex is normally controlled by dynein/dynactin localized via SPDL-1
      Title: A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.
    2. These results suggest that SPDL-1 functions in a kinetochore receptor of MDF-1/MAD1 to induce spindle assembly checkpoint function.
      Title: SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of mitotic cell cycle spindle assembly checkpoint IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic chromosome movement towards spindle pole IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic chromosome movement towards spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of kinetochore assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid arm separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic spindle pole body separation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic spindle pole body separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to kinetochore IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to kinetochore TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Spindly-like protein spdl-1
    NP_495637.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7781566..7783351
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063236.7 → NP_495637.1  Spindly-like protein spdl-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495637.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17695
      Conserved Domains (1) summary
      cl25732
      Location:3 → 224
      SMC_N; RecF/RecN/SMC N terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17695.1

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