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    YPT31 Rab family GTPase YPT31 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YPT31
    Official Full Name
    Rab family GTPase YPT31
    Primary source
    SGD:S000000833
    Locus tag
    YER031C
    See related
    AllianceGenome:SGD:S000000833; FungiDB:YER031C; VEuPathDB:YER031C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YPT8
    Summary
    Enables GTPase activity. Involved in early endosome to Golgi transport and exocytosis. Located in endosome and trans-Golgi network. Orthologous to several human genes including RAB11A (RAB11A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YPT31 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (214076..214747, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein SMB1 Neighboring gene Chz1p Neighboring gene Fir1p Neighboring gene Zrg8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a gene encoding a new Ypt/Rab-like monomeric G-protein in Saccharomyces cerevisiae. Lai MH, et al. Yeast, 1994 Mar. PMID 8017109
    2. A size filtration approach to purify low affinity complexes for crystallization. Ignatev A, et al. J Struct Biol, 2007 Jul. PMID 17408969
    3. Two GTPase isoforms, Ypt31p and Ypt32p, are essential for Golgi function in yeast. Benli M, et al. EMBO J, 1996 Dec 2. PMID 8978673, Free PMC Article
    4. Regulation of Golgi Cisternal Progression by Ypt/Rab GTPases. Kim JJ, et al. Dev Cell, 2016 Feb 22. PMID 26906739, Free PMC Article
    5. Establishing Regulation of a Dynamic Process by Ypt/Rab GTPases : A Case for Cisternal Progression. Kim JJ, et al. Methods Mol Biol, 2021. PMID 34453718

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. that changes in Ypt1 and Ypt31 activity affect Golgi cisternal progression, early-to-transitional and transitional-to-late, respectively
      Title: Regulation of Golgi Cisternal Progression by Ypt/Rab GTPases.
    2. Ypt31 suppresses autophagy defects in trs130 and trs65 mutants.
      Title: Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae.
    3. Ypt31/32 play roles in both the formation of trans-Golgi vesicles and their subsequent Myo2-dependent motility
      Title: Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion.
    4. Ypt31/32 GTPases regulate the function of Rcy1 in the phosphorylation and/or ubiquitination of proteins that recycle through the Golgi
      Title: Ypt31/32 GTPases and their novel F-box effector protein Rcy1 regulate protein recycling.
    5. Ypt31p/32p-Rcy1p pathway regulates putative phospholipid translocases to promote formation of vesicles destined for the trans-Golgi network from early endosomes.
      Title: Endocytic recycling in yeast is regulated by putative phospholipid translocases and the Ypt31p/32p-Rcy1p pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to Golgi transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in recycling endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rab family GTPase YPT31
    NP_010948.1
    • Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication; localizes to the transitional and late Golgi

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      214076..214747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178922.1 → NP_010948.1  TPA: Rab family GTPase YPT31 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010948.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLT0, P38555
      UniProtKB/TrEMBL
      A6ZQY0, B3LS44, B5VHG6, C7GSH8, C8Z733, G2WCR4, N1P4S1
      Conserved Domains (1) summary
      cd01868
      Location:11 → 175
      Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38555.3

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