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    nlf-1 NCA Localization Factor [ Caenorhabditis elegans ]

    Gene ID: 180454, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nlf-1
    Official Full Name
    NCA Localization Factor
    Primary source
    WormBase:WBGene00018854
    Locus tag
    CELE_F55A4.2
    See related
    AllianceGenome:WB:WBGene00018854
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in protein localization to axon and protein-containing complex assembly. Located in endoplasmic reticulum. Is expressed in nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nlf-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    8
    Sequence:
    Chromosome: X; NC_003284.9 (1012715..1017567, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ZP domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Stress-associated endoplasmic reticulum protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Action potentials drive body wall muscle contractions in Caenorhabditis elegans. Gao S, et al. Proc Natl Acad Sci U S A, 2011 Feb 8. PMID 21248227, Free PMC Article
    2. The NCA-1 and NCA-2 Ion Channels Function Downstream of G(q) and Rho To Regulate Locomotion in Caenorhabditis elegans. Topalidou I, et al. Genetics, 2017 May. PMID 28325749, Free PMC Article
    3. NLF-1 delivers a sodium leak channel to regulate neuronal excitability and modulate rhythmic locomotion. Xie L, et al. Neuron, 2013 Mar 20. PMID 23522043
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein localization to axon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NCA Localization Factor
    NP_001350981.1
    • Product from WormBase gene class nlf;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      1012715..1017567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001364050.5 → NP_001350981.1  NCA Localization Factor [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      M4Q8W4
    Nucleotide Protein
    Heading Accession and Version

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