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    ZC328.3 VASt domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZC328.3
    Official Full Name
    VASt domain-containing protein
    Primary source
    WormBase:WBGene00022593
    Locus tag
    CELE_ZC328.3
    See related
    AllianceGenome:WB:WBGene00022593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sterol binding activity and sterol transfer activity. Predicted to be involved in intracellular sterol transport. Predicted to be located in membrane and organelle membrane contact site. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Is expressed in anal sphincter muscle; head; intestine; and pharyngeal-intestinal valve. Orthologous to several human genes including GRAMD1C (GRAM domain containing 1C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ZC328.3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (6409050..6416812, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein cuti-1 Neighboring gene Apple domain-containing protein Neighboring gene BUB1 N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-plasma membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane contact site IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    VASt domain-containing protein
    NP_001040717.1
    • Confirmed by transcript evidence
    NP_001367991.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6409050..6416812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380538.3 → NP_001367991.1  VASt domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2L0J6
      Conserved Domains (2) summary
      cd13220
      Location:88 → 180
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:305 → 453
      DUF4782; Domain of unknown function (DUF4782)

    2. NM_001047252.3 → NP_001040717.1  VASt domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040717.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2MGF5
      Conserved Domains (2) summary
      pfam16016
      Location:78 → 222
      DUF4782; Domain of unknown function (DUF4782)
      pfam14584
      Location:324 → 383
      DUF4446; Protein of unknown function (DUF4446)
    Nucleotide Protein
    Heading Accession and Version

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