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    pho-1 Intestinal acid phosphatase [ Caenorhabditis elegans ]

    Gene ID: 173896, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pho-1
    Official Full Name
    Intestinal acid phosphatase
    Primary source
    WormBase:WBGene00004020
    Locus tag
    CELE_EGAP2.3
    See related
    AllianceGenome:WB:WBGene00004020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatase activity. Located in membrane raft. Is expressed in intestine. Used to study obesity. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pho-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (5233156..5235846, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosome biogenesis GTPase RsgA Neighboring gene DDE_Tnp_ISL3 domain-containing protein Neighboring gene ncRNA Neighboring gene intestinal acid PHOsphatase Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine. Fukushige T, et al. Dev Biol, 2005 Mar 15. PMID 15733671
    2. A gut-to-pharynx/tail switch in embryonic expression of the Caenorhabditis elegans ges-1 gene centers on two GATA sequences. Egan CR, et al. Dev Biol, 1995 Aug. PMID 7649372
    3. DNA-protein interactions in the Caenorhabditis elegans embryo: oocyte and embryonic factors that bind to the promoter of the gut-specific ges-1 gene. Stroeher VL, et al. Dev Biol, 1994 Jun. PMID 8200477
    4. Notch-GATA synergy promotes endoderm-specific expression of ref-1 in C. elegans. Neves A, et al. Development, 2007 Dec. PMID 18003741
    5. Identification and characterization of differentially expressed genes in Caenorhabditis elegans in response to pathogenic and nonpathogenic Stenotrophomonas maltophilia. Radeke LJ, et al. BMC Microbiol, 2020 Jun 19. PMID 32560629, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that pho-1 is required by the maternal intestine to assimilate some nutrient or cleavage product that is subsequently provided to the next generation of embryos.
      Title: Transcriptional control and patterning of the pho-1 gene, an essential acid phosphatase expressed in the C. elegans intestine.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft HDA PubMed 
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Intestinal acid phosphatase
    NP_494983.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5233156..5235846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062582.5 → NP_494983.1  Intestinal acid phosphatase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494983.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19076
      Conserved Domains (1) summary
      pfam00328
      Location:27 → 371
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19076.1

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