hpo-8 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: hpo-8
Official Full Name: Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8
Primary source: WormBase:WBGene00020517
Locus tag: CELE_T15B7.2
See related: AllianceGenome:WB:WBGene00020517
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 3-hydroxyacyl-CoA dehydratase activity. Predicted to be involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in gonadal sheath cell. Human ortholog(s) of this gene implicated in congenital myopathy. Orthologous to several human genes including HACD2 (3-hydroxyacyl-CoA dehydratase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 3-hydroxyacyl-CoA dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

NP_504740.2

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