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    dod-22 CUB-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 178247, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dod-22
    Official Full Name
    CUB-like domain-containing protein
    Primary source
    WormBase:WBGene00010125
    Locus tag
    CELE_F55G11.5
    See related
    AllianceGenome:WB:WBGene00010125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-negative bacterium and innate immune response. Is expressed in head neurons; intestine; and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dod-22 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (12965374..12967392)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene CUB-like domain-containing protein Neighboring gene CUB-like domain-containing protein Neighboring gene CUB-like domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vibrio cholerae hemolysin is required for lethality, developmental delay, and intestinal vacuolation in Caenorhabditis elegans. Cinar HN, et al. PLoS One, 2010 Jul 13. PMID 20644623, Free PMC Article
    2. Caenorhabditis elegans LIN-24, a homolog of bacterial pore-forming toxin, protects the host from microbial infection. Zhang H, et al. FASEB J, 2023 Oct. PMID 37682220
    3. Biosafety assessment of Acinetobacter strains isolated from the Three Gorges Reservoir region in nematode Caenorhabditis elegans. Deng Y, et al. Sci Rep, 2021 Oct 5. PMID 34611259, Free PMC Article
    4. Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans. Sahu SN, et al. PLoS One, 2012. PMID 22675448, Free PMC Article
    5. Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family. Greiss S, et al. BMC Genomics, 2008 Jul 15. PMID 18627611, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response HEP PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CUB-like domain-containing protein
    NP_001255689.1
    • Confirmed by transcript evidence
    NP_001255690.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      12965374..12967392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268760.2 → NP_001255689.1  CUB-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUE0
      Conserved Domains (2) summary
      pfam02408
      Location:15 → 132
      CUB_2; CUB-like domain
      cl21464
      Location:223 → 340
      cupin_like; Conserved domain found in cupin and related proteins

    2. NM_001268761.3 → NP_001255690.1  CUB-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255690.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5MCV0
      Conserved Domains (2) summary
      pfam02408
      Location:1 → 90
      CUB_2; CUB-like domain
      cl21464
      Location:181 → 298
      cupin_like; Conserved domain found in cupin and related proteins
    Nucleotide Protein
    Heading Accession and Version

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