hif-1 Hypoxia-inducible factor 1;PAS domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hif-1
Official Full Name: Hypoxia-inducible factor 1;PAS domain-containing protein
Primary source: WormBase:WBGene00001851
Locus tag: CELE_F38A6.3
See related: AllianceGenome:WB:WBGene00001851
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables DNA-binding transcription factor activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to caloric restriction; determination of adult lifespan; and heat acclimation. Located in nucleus. Is expressed widely. Used to study cancer and cardiovascular system disease. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1) and HIF3A (hypoxia inducible factor 3 subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hif-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (20780407..20785260)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in Caenorhabditis elegans.
Title: Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in Caenorhabditis elegans.
The rhy-1 gene encodes a predicated O-acyltransferase enzyme that has previously been shown to negatively regulate HIF-1 activity. Our data indicate that RHY-1 has novel, hif-1 independent, function that promotes survival in H2S.
Title: A Novel Mechanism To Prevent H(2)S Toxicity in Caenorhabditis elegans.
The authors discovered that a HIF target, the Caenorhabditis elegans gene cyp-36A1, is required for numerous HIF-dependent processes, including modulation of gene expression, stress resistance, and behavior.
Title: Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor.
Our results suggest that these detoxification pathways are mediated by the hypoxia inducible factor HIF-1. Finally, we show that sulfide resistance varies among wild C. elegans and other nematode species, suggesting that tolerance to sulfide was naturally selected in certain habitats.
Title: Mechanisms of defense against products of cysteine catabolism in the nematode Caenorhabditis elegans.
blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function.
Title: Loss of hif-1 promotes resistance to the exogenous mitochondrial stressor ethidium bromide in Caenorhabditis elegans.
HIF-1-mediated activation of 5-HT signalling promotes axon regeneration by activating both the RhoA and cAMP pathways.
Title: Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans.
this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2).
Title: Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.
AMPK and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS
Title: Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.
Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.
Title: Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1.
HIF can function either as a gene-specific inducer or repressor of host defense, providing a molecular mechanism by which HIF can have apparently opposing roles in defense and inflammation.
Title: EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F38A6.3 (e-PCR)
- UniSTS:317488

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to caloric restriction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hypoxia-inducible factor 1;PAS domain-containing protein

NP_001023891.2

Confirmed by transcript evidence

NP_001023892.1

Partially confirmed by transcript evidence

NP_001023894.2

Confirmed by transcript evidence

NP_001299994.1

Confirmed by transcript evidence

NP_001359648.1

Partially confirmed by transcript evidence

NP_508008.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

20780407..20785260

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028720.5 → NP_001023891.2 Hypoxia-inducible factor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023891.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGD2

Conserved Domains (3) summary

cd00083
Location:10 → 66

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:94 → 145

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam14598
Location:236 → 338

PAS_11; PAS domain
NM_001373210.2 → NP_001359648.1 Hypoxia-inducible factor 1 [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (3) summary

smart00091
Location:89 → 142

PAS; PAS domain

pfam14598
Location:236 → 338

PAS_11; PAS domain

cl00081
Location:12 → 66

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
NM_075607.8 → NP_508008.4 Hypoxia-inducible factor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508008.4

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECE6, G5EDZ3, G5EE28, G5EGD2, Q8I4D0

Conserved Domains (3) summary

cd00083
Location:10 → 66

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:94 → 145

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam14598
Location:236 → 338

PAS_11; PAS domain
NM_001313065.3 → NP_001299994.1 PAS domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AXG6

Conserved Domains (3) summary

cd00083
Location:2 → 58

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:86 → 137

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam14598
Location:228 → 330

PAS_11; PAS domain
NM_001028723.4 → NP_001023894.2 Hypoxia-inducible factor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023894.2

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGD2

Conserved Domains (3) summary

cd00083
Location:2 → 58

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:86 → 137

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam14598
Location:228 → 330

PAS_11; PAS domain
NM_001028721.6 → NP_001023892.1 Hypoxia-inducible factor 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023892.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EGD2

Conserved Domains (2) summary

cd00130
Location:17 → 96

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam14598
Location:20 → 122

PAS_11; PAS domain