baz-2 Bromodomain adjacent to zinc finger domain protein 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: baz-2
Official Full Name: Bromodomain adjacent to zinc finger domain protein 2
Primary source: WormBase:WBGene00001470
Locus tag: CELE_ZK783.4
See related: AllianceGenome:WB:WBGene00001470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity and metal ion binding activity. Involved in epigenetic regulation of gene expression. Located in chromatin. Is expressed in several structures, including AB lineage cell; hermaphrodite gonad; hypodermis; neurons; and vulva. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A) and BAZ2B (bromodomain adjacent to zinc finger domain 2B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See baz-2 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (7650553..7656032, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

baz-2 enhances systemic proteostasis in vivo by regulating acetylcholine metabolism.
Title: baz-2 enhances systemic proteostasis in vivo by regulating acetylcholine metabolism.
a neuronal epigenetic reader, BAZ-2, and a neuronal histone 3 lysine 9 methyltransferase, SET-6, accelerate behavioural deterioration in C. elegans by reducing mitochondrial function, repressing the expression of nuclear-encoded mitochondrial proteins; genome-wide RNA-interference screen in C. elegans has unravelled conserved epigenetic negative regulators of ageing, suggesting possible ways to achieve healthy ageing
Title: Two conserved epigenetic regulators prevent healthy ageing.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK783.4 (e-PCR)
- UniSTS:310546

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in epigenetic regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IMP Inferred from Mutant Phenotype more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in intracellular organelle	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Bromodomain adjacent to zinc finger domain protein 2

NP_498673.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7650553..7656032 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066272.6 → NP_498673.3 Bromodomain adjacent to zinc finger domain protein 2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498673.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23590

Conserved Domains (8) summary

cd05503
Location:1278 → 1374

Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...

smart00249
Location:1155 → 1199

PHD; PHD zinc finger

cd01397
Location:328 → 401

HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...

cd15545
Location:1102 → 1146

PHD_BAZ2A_like; PHD finger found in bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) and 2B (BAZ2B)

pfam15612
Location:623 → 665

WHIM1; WSTF, HB1, Itc1p, MBD9 motif 1

pfam15613
Location:796 → 823

WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif

NF033900
Location:33 → 96

T4SS_IcmE_DotG; type IVB secretion system protein DotG/IcmE

cl02674
Location:524 → 564

DDT; DDT domain