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    flh-1 FLYWCH transcription factor 1 [ Caenorhabditis elegans ]

    Gene ID: 177749, updated on 2-Nov-2024

    Summary

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    Official Symbol
    flh-1
    Official Full Name
    FLYWCH transcription factor 1
    Primary source
    WormBase:WBGene00012435
    Locus tag
    CELE_Y11D7A.12
    See related
    AllianceGenome:WB:WBGene00012435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription and nematode larval development. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See flh-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    4
    Sequence:
    Chromosome: IV; NC_003282.8 (9261807..9264270, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Complex I-B8;NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4;Transposase Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Neighboring gene FLYWCH transcription factor 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Predicting mutation outcome from early stochastic variation in genetic interaction partners. Burga A, et al. Nature, 2011 Dec 7. PMID 22158248
    2. The FLYWCH transcription factors FLH-1, FLH-2, and FLH-3 repress embryonic expression of microRNA genes in C. elegans. Ow MC, et al. Genes Dev, 2008 Sep 15. PMID 18794349, Free PMC Article
    3. DNA binding and in vivo function of C.elegans PEB-1 require a conserved FLYWCH motif. Beaster-Jones L, et al. J Mol Biol, 2004 Jun 11. PMID 15165844
    4. Transcriptional control of microRNA expression in C. elegans: promoting better understanding. Turner MJ, et al. RNA Biol, 2009 Jan-Mar. PMID 19106630, Free PMC Article
    5. miRNAs give worms the time of their lives: small RNAs and temporal control in Caenorhabditis elegans. Resnick TD, et al. Dev Dyn, 2010 May. PMID 20232378, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FLYWCH transcription factor 1
    NP_001122806.1
    • Partially confirmed by transcript evidence
    NP_001255383.1
    • Confirmed by transcript evidence
    NP_501618.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9261807..9264270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129334.4 → NP_001122806.1  FLYWCH transcription factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A7DTF1
      Conserved Domains (1) summary
      pfam04500
      Location:133 → 192
      FLYWCH; FLYWCH zinc finger domain

    2. NM_069217.9 → NP_501618.2  FLYWCH transcription factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501618.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A7DTF1, D3NQA3, Q9XWR1
      Conserved Domains (1) summary
      pfam04500
      Location:133 → 192
      FLYWCH; FLYWCH zinc finger domain

    3. NM_001268454.3 → NP_001255383.1  FLYWCH transcription factor 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255383.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3NQA3
      Conserved Domains (1) summary
      pfam04500
      Location:127 → 186
      FLYWCH; FLYWCH zinc finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XWR1.2

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