tank-1 Poly [ADP-ribose] polymerase tankyrase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tank-1
Official Full Name: Poly [ADP-ribose] polymerase tankyrase
Primary source: WormBase:WBGene00004053
Locus tag: CELE_ZK1005.1
See related: AllianceGenome:WB:WBGene00004053
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of programmed cell death; and response to gamma radiation. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tank-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (1276415..1285707, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PME-5 is a ubiquitous nuclear protein expressed throughout the development of the worm and is closely linked to chromatin and condensed chromosomes.
Title: The DNA damage-inducible C. elegans tankyrase is a nuclear protein closely linked to chromosomes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK1005.1 (e-PCR)
- UniSTS:310397

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Poly [ADP-ribose] polymerase tankyrase

NP_001024306.1

Confirmed by transcript evidence

NP_503401.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

1276415..1285707 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029135.6 → NP_001024306.1 Poly [ADP-ribose] polymerase tankyrase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024306.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9TXQ1

Conserved Domains (7) summary

cd07997
Location:1755 → 1858

WGR_PARP; WGR domain of poly(ADP-ribose) polymerases

COG0666
Location:529 → 769

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:456 → 584

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01437
Location:1872 → 2238

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00644
Location:2040 → 2238

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam12796
Location:503 → 591

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:501 → 529

ANK; ANK repeat [structural motif]
NM_071000.9 → NP_503401.3 Poly [ADP-ribose] polymerase tankyrase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_503401.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8I0N5, Q9TXQ1

Conserved Domains (7) summary

cd07997
Location:1793 → 1896

WGR_PARP; WGR domain of poly(ADP-ribose) polymerases

COG0666
Location:529 → 769

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:456 → 584

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd01437
Location:1910 → 2276

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00644
Location:2078 → 2276

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam12796
Location:503 → 591

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:501 → 529

ANK; ANK repeat [structural motif]