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    nuc-1 Deoxyribonuclease-2 [ Caenorhabditis elegans ]

    Gene ID: 181174, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nuc-1
    Official Full Name
    Deoxyribonuclease-2
    Primary source
    WormBase:WBGene00003828
    Locus tag
    CELE_C07B5.5
    See related
    AllianceGenome:WB:WBGene00003828
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Acts upstream of or within with a positive effect on negative regulation of antimicrobial peptide production. Located in lysosome. Is expressed in body wall musculature; head; intestinal cell; and vulva. Orthologous to human DNASE2B (deoxyribonuclease 2 beta) and DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See nuc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (9539905..9542329)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Nucleolar protein 16;Translation initiation factor IF-2 Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Post-embryonic development in the ventral cord of Caenorhabditis elegans. Sulston JE. Philos Trans R Soc Lond B Biol Sci, 1976 Aug 10. PMID 8804
    2. Nematodes Degrade Extracellular Antibiotic Resistance Genes by Secreting DNase II Encoded by the nuc-1 Gene. Dong W, et al. Environ Sci Technol, 2023 Aug 15. PMID 37523858
    3. An endonuclease from Caenorhabditis elegans: partial purification and characterization. Hevelone J, et al. Biochem Genet, 1988 Aug. PMID 3228446
    4. Structure, evolution and properties of a novel repetitive DNA family in Caenorhabditis elegans. La Volpe A, et al. Nucleic Acids Res, 1988 Sep 12. PMID 3419918, Free PMC Article
    5. The C. elegans apoptotic nuclease NUC-1 is related in sequence and activity to mammalian DNase II. Lyon CJ, et al. Gene, 2000 Jul 11. PMID 10903446

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuc-1 is principally responsible for degradation of apoptotic DNA during embryogenesis.
      Title: Autonomous and non-autonomous roles of DNase II during cell death in C. elegans embryos.
    2. Nuc-1 plays a role in degrading apoptotic DNA in distinct sites of the gonad.
      Title: Loss of DNase II function in the gonad is associated with a higher expression of antimicrobial genes in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables deoxyribonuclease II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribonuclease II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyribonuclease II activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic DNA fragmentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within_positive_effect negative regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Deoxyribonuclease-2
    NP_509604.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9539905..9542329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077203.9 → NP_509604.1  Deoxyribonuclease-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17778
      Conserved Domains (3) summary
      cd09120
      Location:21 → 191
      PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins
      cd09121
      Location:238 → 374
      PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins
      pfam03265
      Location:24 → 371
      DNase_II; Deoxyribonuclease II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17778.1

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