nuaf-1 putative complex I intermediate-associated protein 30, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: nuaf-1
Official Full Name: putative complex I intermediate-associated protein 30, mitochondrial
Primary source: WormBase:WBGene00008225
Locus tag: CELE_C50B8.3
See related: AllianceGenome:WB:WBGene00008225
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable unfolded protein binding activity. Involved in mitochondrial respiratory chain complex I assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 11. Orthologous to human NDUFAF1 (NADH:ubiquinone oxidoreductase complex assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nuaf-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 5

Sequence:: Chromosome: V; NC_003283.11 (13566931..13568630, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We demonstrate that two candidates (C50B8.3/NUAF-1, homologue of NDUFAF1 and R07H5.3/NUAF-3, homologue of NDUFAF3) clearly affect complex I function.
Title: Identification and functional analysis of mitochondrial complex I assembly factor homologues in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C50B8.3 (e-PCR)
- UniSTS:313914

C50B8.2 (e-PCR)
- UniSTS:309357

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial respiratory chain complex I assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative complex I intermediate-associated protein 30, mitochondrial

NP_506361.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13566931..13568630 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073960.5 → NP_506361.1 putative complex I intermediate-associated protein 30, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506361.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18726

Conserved Domains (1) summary

pfam08547
Location:139 → 310

CIA30; Complex I intermediate-associated protein 30 (CIA30)