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    tba-2 Tubulin alpha-2 chain [ Caenorhabditis elegans ]

    Gene ID: 173167, updated on 27-Dec-2024

    Summary

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    Official Symbol
    tba-2
    Official Full Name
    Tubulin alpha-2 chain
    Primary source
    WormBase:WBGene00006529
    Locus tag
    CELE_C47B2.3
    See related
    AllianceGenome:WB:WBGene00006529
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in several processes, including centrosome localization; establishment of mitotic spindle orientation; and regulation of cytokinesis. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including body wall musculature; intestine; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal dominant isolated macrothrombocytopenia 2. Orthologous to human TUBA8 (tubulin alpha 8) and TUBAL3 (tubulin alpha like 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tba-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (12964674..12966271, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene Uracil phosphoribosyltransferase homolog Neighboring gene Proteasome subunit beta Neighboring gene Eukaryotic translation initiation factor 6 Neighboring gene UDP-glucose 4-epimerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective expression of the tba-1 alpha tubulin gene in a set of mechanosensory and motor neurons during the development of Caenorhabditis elegans. Fukushige T, et al. Biochim Biophys Acta, 1995 Apr 26. PMID 7742369
    2. The Structure and Dynamics of C. elegans Tubulin Reveals the Mechanistic Basis of Microtubule Growth. Chaaban S, et al. Dev Cell, 2018 Oct 22. PMID 30245157
    3. Chronic exposure to methylmercury induces puncta formation in cephalic dopaminergic neurons in Caenorhabditis elegans. Ke T, et al. Neurotoxicology, 2020 Mar. PMID 31935438, Free PMC Article
    4. MEC-12, an alpha-tubulin required for touch sensitivity in C. elegans. Fukushige T, et al. J Cell Sci, 1999 Feb. PMID 9885292
    5. Mutations in a beta-tubulin disrupt spindle orientation and microtubule dynamics in the early Caenorhabditis elegans embryo. Wright AJ, et al. Mol Biol Cell, 2003 Nov. PMID 12937270, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tubulin alpha-2 chain
    NP_001021050.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12964674..12966271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001025879.7 → NP_001021050.1  Tubulin alpha-2 chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021050.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34690, Q95QR1
      UniProtKB/TrEMBL
      Q17409
      Conserved Domains (1) summary
      PTZ00335
      Location:1 → 437
      PTZ00335; tubulin alpha chain; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34690.1

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