U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    blos-1 Biogenesis of lysosome-related organelles complex 1 subunit 1 [ Caenorhabditis elegans ]

    Gene ID: 176435, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    blos-1
    Official Full Name
    Biogenesis of lysosome-related organelles complex 1 subunit 1
    Primary source
    WormBase:WBGene00011872
    Locus tag
    CELE_T20G5.10
    See related
    AllianceGenome:WB:WBGene00011872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in endosomal transport. Predicted to be located in cytosol; mitochondrial intermembrane space; and mitochondrial matrix. Predicted to be part of BLOC-1 complex. Is expressed in excretory cell; intestine; and nervous system. Orthologous to human BLOC1S1 (biogenesis of lysosomal organelles complex 1 subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See blos-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (10211002..10211946, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene ncRNA Neighboring gene putative clathrin heavy chain 1 Neighboring gene Partner of Y14 and mago Neighboring gene Bestrophin homolog;Bestrophin homolog 18 Neighboring gene putative citrate synthase, mitochondrial Neighboring gene DRBM domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Complementary RNA amplification methods enhance microarray identification of transcripts expressed in the C. elegans nervous system. Watson JD, et al. BMC Genomics, 2008 Feb 19. PMID 18284693, Free PMC Article
    2. BORC Regulates the Axonal Transport of Synaptic Vesicle Precursors by Activating ARL-8. Niwa S, et al. Curr Biol, 2017 Sep 11. PMID 28823680, Free PMC Article
    3. C. elegans BLOC-1 functions in trafficking to lysosome-related gut granules. Hermann GJ, et al. PLoS One, 2012. PMID 22916203, Free PMC Article
    4. A BORC-dependent molecular pathway for vesiculation of cell corpse phagolysosomes. Fazeli G, et al. Curr Biol, 2023 Feb 27. PMID 36652947, Free PMC Article
    5. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of BLOC-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of BLOC-1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of BLOC-1 complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Biogenesis of lysosome-related organelles complex 1 subunit 1
    NP_499262.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10211002..10211946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066861.5 → NP_499262.2  Biogenesis of lysosome-related organelles complex 1 subunit 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22616
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous