mtx-1 Metaxin-1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mtx-1
Official Full Name: Metaxin-1 homolog
Primary source: WormBase:WBGene00009559
Locus tag: CELE_F39B2.11
See related: AllianceGenome:WB:WBGene00009559
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in mitochondrion organization. Predicted to be located in mitochondrial outer membrane. Predicted to be part of SAM complex. Predicted to be active in cytoplasm. Orthologous to several human genes including MTX3 (metaxin 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mtx-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (14755154..14756412, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Metaxins are core components of mitochondrial transport adaptor complexes.
Title: Metaxins are core components of mitochondrial transport adaptor complexes.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F39B2.10 (e-PCR)
- UniSTS:310207

F39B2.11 (e-PCR)
- UniSTS:310208

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SAM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SAM complex	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Metaxin-1 homolog

NP_493569.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

14755154..14756412 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_061168.7 → NP_493569.1 Metaxin-1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_493569.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45503

Conserved Domains (2) summary

cd03212
Location:106 → 231

GST_C_Metaxin1_3; C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins

cd03078
Location:1 → 76

GST_N_Metaxin1_like; GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the ...