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    unc-58 Potassium channel domain-containing protein;Uncoordinated protein 58 [ Caenorhabditis elegans ]

    Gene ID: 181224, updated on 9-Dec-2024

    Summary

    Official Symbol
    unc-58
    Official Full Name
    Potassium channel domain-containing protein;Uncoordinated protein 58
    Primary source
    WormBase:WBGene00006792
    Locus tag
    CELE_T06H11.1
    See related
    AllianceGenome:WB:WBGene00006792
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables outward rectifier potassium channel activity. Involved in several processes, including muscle contraction; parturition; and regulation of muscle contraction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in interneuron and motor neurons. Orthologous to human KCNK17 (potassium two pore domain channel subfamily K member 17) and KCNK5 (potassium two pore domain channel subfamily K member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See unc-58 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    22
    Sequence:
    Chromosome: X; NC_003284.9 (10104610..10133182, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene glutamate synthase (NADH) Neighboring gene SPREPIRF-amide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene MoaB/Mog domain-containing protein Neighboring gene Nose resistant-to-fluoxetine protein N-terminal domain-containing protein

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables outward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in parturition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Potassium channel domain-containing protein;Uncoordinated protein 58
    NP_001360790.1
    • Confirmed by transcript evidence
    NP_001360791.1
    • Partially confirmed by transcript evidence
    NP_001360792.1
    • Partially confirmed by transcript evidence
    NP_001360793.1
    • Partially confirmed by transcript evidence
    NP_001360794.1
    • Confirmed by transcript evidence
    NP_741880.1
    • Confirmed by transcript evidence
    NP_741881.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      10104610..10133182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171759.6NP_741881.1  Uncoordinated protein 58 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741881.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22271, Q8MPX9
      Conserved Domains (1) summary
      pfam07885
      Location:284344
      Ion_trans_2; Ion channel
    2. NM_001373458.4NP_001360790.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKM3
      Conserved Domains (1) summary
      pfam07885
      Location:211267
      Ion_trans_2; Ion channel
    3. NM_001373459.2NP_001360794.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INP7
      Conserved Domains (1) summary
      pfam07885
      Location:207263
      Ion_trans_2; Ion channel
    4. NM_001373460.3NP_001360792.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IL39
      Conserved Domains (1) summary
      pfam07885
      Location:184240
      Ion_trans_2; Ion channel
    5. NM_001373456.2NP_001360793.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0INX3
      Conserved Domains (1) summary
      pfam07885
      Location:299355
      Ion_trans_2; Ion channel
    6. NM_171758.5NP_741880.1  Uncoordinated protein 58 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741880.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22271
      Conserved Domains (1) summary
      pfam07885
      Location:246306
      Ion_trans_2; Ion channel
    7. NM_001373457.2NP_001360791.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IKI8
      Conserved Domains (1) summary
      pfam07885
      Location:259315
      Ion_trans_2; Ion channel