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    unc-119 GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119 [ Caenorhabditis elegans ]

    Gene ID: 176519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-119
    Official Full Name
    GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119
    Primary source
    WormBase:WBGene00006843
    Locus tag
    CELE_M142.1
    See related
    AllianceGenome:WB:WBGene00006843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lipid binding activity. Involved in several processes, including negative regulation of axon extension; regulation of egg-laying behavior; and regulation of nematode pharyngeal pumping. Located in axon. Is expressed in several structures, including body wall musculature; ganglia; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cone-rod dystrophy 24 and immunodeficiency 13. Orthologous to human UNC119 (unc-119 lipid binding chaperone) and UNC119B (unc-119 lipid binding chaperone B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-119 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (10902641..10908935)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene DNA endonuclease activator Ctp1 C-terminal domain-containing protein Neighboring gene Cuticlin-6 Neighboring gene Homeobox protein vab-7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SapTrap assembly of repair templates for Cas9-triggered homologous recombination with a self-excising cassette. Dickinson D, et al. MicroPubl Biol, 2018 May 1. PMID 32550377, Free PMC Article
    2. Biolistic transformation of Caenorhabditis elegans. Isik M, et al. Methods Mol Biol, 2013. PMID 23104335
    3. phiC31 integrase for recombination-mediated single-copy insertion and genome manipulation in Caenorhabditis elegans. Yang FJ, et al. Genetics, 2022 Feb 4. PMID 34791215, Free PMC Article
    4. Quantitative PCR approach to SNP detection and linkage mapping in Caenorhabditis elegans. Shelton CA. Biotechniques, 2006 Nov. PMID 17140115
    5. Novel Caenorhabditis elegans unc-119 axon outgrowth defects correlate with behavioral phenotypes that are partially rescued by nonneural unc-119. Materi W, et al. Genesis, 2005 Jun. PMID 15892079

    See all (158) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors demonstrate that ARL-3 is a unique small GTPase with unusual high intrinsic GDP release but low intrinsic GTP binding rate. Importantly, ARL-13 acts as a nucleotide exchange factor (GEF) of ARL-3, while UNC-119 can stabilize the GTP binding of ARL-3. We further show that excess inactivated ARL-3 compromises ciliogenesis.
      Title: GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119.
    2. we show that removal of either of two critical P-granule components, PGL-1 or GLH-1, is sufficient to cause germ cells to express UNC-119::GFP and MYO-3 and to display RNA accumulation defects similar to those observed after depletion of P granules. Our data identify P granules as critical modulators of the germline transcriptome and guardians of germ cell fate.
      Title: Germ Granules Prevent Accumulation of Somatic Transcripts in the Adult Caenorhabditis elegans Germline.
    3. the RIBEYE-Munc119 interaction is essential for synaptic transmission at the photoreceptor ribbon synapse.
      Title: RIBEYE recruits Munc119, a mammalian ortholog of the Caenorhabditis elegans protein unc119, to synaptic ribbons of photoreceptor synapses.
    4. Unc-119 mutants result in age-related effects on M2 neurons.
      Title: A genetic analysis of axon guidance in the C elegans pharynx.
    5. UNC-119 function is necessary for the correct development of the Caenorhabditis elegans nervous system
      Title: Novel Caenorhabditis elegans unc-119 axon outgrowth defects correlate with behavioral phenotypes that are partially rescued by nonneural unc-119.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipoprotein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GMP phosphodiesterase delta subunit domain-containing protein;Protein unc-119
    NP_001255088.1
    • Confirmed by transcript evidence
    NP_001255089.1
    • Confirmed by transcript evidence
    NP_001255090.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10902641..10908935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268159.3 → NP_001255088.1  GMP phosphodiesterase delta subunit domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255088.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGP9
      Conserved Domains (1) summary
      pfam05351
      Location:89 → 242
      GMP_PDE_delta; GMP-PDE, delta subunit

    2. NM_001268160.4 → NP_001255089.1  Protein unc-119 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255089.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10658
      Conserved Domains (1) summary
      pfam05351
      Location:64 → 217
      GMP_PDE_delta; GMP-PDE, delta subunit

    3. NM_001268161.3 → NP_001255090.1  GMP phosphodiesterase delta subunit domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255090.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0P283
      Conserved Domains (1) summary
      pfam05351
      Location:45 → 197
      GMP_PDE_delta; GMP-PDE, delta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10658.1

    Gene LinkOut

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