arp-6 Actin-like protein C08B11.6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: arp-6
Official Full Name: Actin-like protein C08B11.6
Primary source: WormBase:WBGene00007434
Locus tag: CELE_C08B11.6
See related: AllianceGenome:WB:WBGene00007434
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable nucleosome binding activity. Predicted to be located in cytoplasm; cytoskeleton; and nucleus. Predicted to be part of Swr1 complex. Orthologous to human ACTR6 (actin related protein 6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See arp-6 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (8035877..8037346, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that UNC-87 competes with ADF/cofilin (unc-60) for binding to actin filaments and inhibits ADF/cofilin-dependent filament severing and depolymerization in vitro.
Title: UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C08B11.5 (e-PCR)
- UniSTS:309000

C08B11.6 (e-PCR)
- UniSTS:309001

C08B11.7 (e-PCR)
- UniSTS:309002

STS2-162 (e-PCR)
- UniSTS:241832

C08B11.9 (e-PCR)
- UniSTS:320685

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Swr1 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Actin-like protein C08B11.6

NP_495681.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8035877..8037346 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063280.7 → NP_495681.4 Actin-like protein C08B11.6 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495681.4

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09443, Q17351

Conserved Domains (2) summary

smart00268
Location:4 → 388

ACTIN; Actin

COG5277
Location:2 → 380

COG5277; Actin-related protein [Cytoskeleton]