U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tyr-2 ShKT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176810, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tyr-2
    Official Full Name
    ShKT domain-containing protein
    Primary source
    WormBase:WBGene00010661
    Locus tag
    CELE_K08E3.1
    See related
    AllianceGenome:WB:WBGene00010661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables dopachrome isomerase activity. Involved in negative regulation of apoptotic process. Is expressed in hypodermis and uterine muscle. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to several human genes including TYR (tyrosinase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See tyr-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (13744222..13747287)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene Major sperm protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. New insights into the evolution of metazoan tyrosinase gene family. Esposito R, et al. PLoS One, 2012. PMID 22536431, Free PMC Article
    2. HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Sendoel A, et al. Nature, 2010 Jun 3. PMID 20520707, Free PMC Article
    3. Genetic interaction with temperature is an important determinant of nematode longevity. Miller H, et al. Aging Cell, 2017 Dec. PMID 28940623, Free PMC Article
    4. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dopachrome isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    ShKT domain-containing protein
    NP_499836.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13744222..13747287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067435.8 → NP_499836.1  ShKT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499836.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUS8
      Conserved Domains (3) summary
      smart00254
      Location:586 → 621
      ShKT; ShK toxin domain
      pfam00264
      Location:188 → 376
      Tyrosinase; Common central domain of tyrosinase
      pfam01549
      Location:541 → 576
      ShK; ShK domain-like
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous