hmg-4 FACT complex subunit SSRP1-A [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hmg-4
Official Full Name: FACT complex subunit SSRP1-A
Primary source: WormBase:WBGene00001974
Locus tag: CELE_T20B12.8
See related: AllianceGenome:WB:WBGene00001974
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable histone binding activity and nucleosome binding activity. Involved in nematode pharynx development and regulation of embryonic development. Located in nucleus. Is expressed in several structures, including germ line; head muscle; neurons; somatic cell; and somatic nervous system. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See hmg-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 4

Sequence:: Chromosome: III; NC_003281.10 (7379143..7381596, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T20B12.3 (e-PCR)
- UniSTS:306282

T20B12.8 (e-PCR)
- UniSTS:310901

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in nematode pharynx development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of chromatin organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of embryonic development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of FACT complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FACT complex subunit SSRP1-A

NP_498633.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

7379143..7381596 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_066232.7 → NP_498633.1 FACT complex subunit SSRP1-A [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498633.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P41848

Conserved Domains (3) summary

cd01390
Location:556 → 619

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

cd13231
Location:332 → 429

PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2

pfam03531
Location:75 → 285

SSrecog; Structure-specific recognition protein (SSRP1)